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Encyclopedia of Cancer pp 1–5Cite as

Stress Response

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Synonyms

Damage response; Immediate early stress response

Definition

Stress response is a process that occurs in response to an imbalance of cellular homeostasis following altered external and internal stimuli.

Characteristics

A cellular stress response consists of cellular changes required to accommodate internal or external insult. Recognition of stress occurs by sensing of alterations in essential macromolecules, which include DNA damage, protein misfolding/aggregation, or damage of membrane lipids. Most cellular stresses are accompanied by changes in cellular redox potential, another key regulatory event in the sensing and activation of the cellular stress response. A large set of cellular sensors, which include redox-sensitive proteins, cell surface receptors, and proteins that recognize changes in ROS, proteostasis, or DNA damage, regulate the activity of stress kinases and their respective substrates. Stress kinase signaling regulates transcriptional, translational, and...

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References

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Author information

Authors and Affiliations

  1. Signal Transduction Program, Burnham Institute for Medical Research, La Jolla, CA, USA

    Ze’ev Ronai

Authors
  1. Ze’ev Ronai
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Corresponding author

Correspondence to Ze’ev Ronai .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2015 Springer-Verlag Berlin Heidelberg

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Ronai, Z. (2015). Stress Response. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_5528-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_5528-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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