Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Stress Response

  • Ze’ev Ronai
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5528-2



Stress response is a process that occurs in response to an imbalance of cellular homeostasis following altered external and internal stimuli.


A cellular stress response consists of cellular changes required to accommodate internal or external insult. Recognition of stress occurs by sensing of alterations in essential macromolecules, which include DNA damage, protein misfolding/aggregation, or damage of membrane lipids. Most cellular stresses are accompanied by changes in cellular redox potential, another key regulatory event in the sensing and activation of the cellular stress response. A large set of cellular sensors, which include redox-sensitive proteins, cell surface receptors, and proteins that recognize changes in ROS, proteostasis, or DNA damage, regulate the activity of stress kinases and their respective substrates. Stress kinase signaling regulates transcriptional, translational, and...


Unfold Protein Response Heat Shock Transcription Factor Cellular Stress Response Stress Kinase Adaptive Program 
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  1. Adler V, Yin Z, Tew KD et al (1999) Role of redox potential and reactive oxygen species in stress signaling. Oncogene 18:6104–6111CrossRefPubMedGoogle Scholar
  2. Gutierrez GJ Ronai Z (2006) Ubiquitin and SUMO systems in the regulation of mitotic checkpoints. Trends Biochem Sci 31:324–332CrossRefPubMedPubMedCentralGoogle Scholar
  3. Han J, Back SH, Hur J et al. (2013) ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nat Cell Biol 15:481–90.CrossRefPubMedPubMedCentralGoogle Scholar
  4. Kultz D (2005) Molecular and evolutionary basis of the cellular stress response. Annu Rev Physiol 67:225–57.CrossRefPubMedGoogle Scholar
  5. Liu B, Qian SB (2014) Translational reprogramming in cellular stress response. Wiley Interdiscip Rev RNA 5:301–15.CrossRefPubMedPubMedCentralGoogle Scholar
  6. Lopez-Bergami P (2011) The role of mitogen- and stress-activated protein kinase pathways in melanoma. Pigment Cell Melanoma Res 24:902–21.CrossRefPubMedGoogle Scholar
  7. Richter K, Haslbeck M, Buchner J (2010) The heat shock response: life on the verge of death. Mol Cell 40:253–66.CrossRefPubMedGoogle Scholar
  8. Roesch A, Paschen A, Landsberg J et al. (2016) Phenotypic tumour cell plasticity as a resistance mechanism and therapeutic target in melanoma. Eur J Cancer 59:109–12.CrossRefPubMedGoogle Scholar
  9. Roos WP, Thomas AD, Kaina B (2016) DNA damage and the balance between survival and death in cancer biology. Nat Rev Cancer 16:20–33.CrossRefPubMedGoogle Scholar
  10. Senft D, Ronai ZA (2015) UPR, autophagy, and mitochondria crosstalk underlies the ER stress response. Trends Biochem Sci 40:141–8.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Signal Transduction ProgramBurnham Institute for Medical ResearchLa JollaUSA