Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5510-2



STI-571 is an oral drug marketed by Novartis and is currently used for the treatment of certain types of cancer(s), including chronic myeloid leukemia (CML) and gastrointestinal stromal tumor (GIST).


Physicochemical Properties

STI-571 is a small compound belonging to the phenylaminopyrimidine class of compounds (Fig. 1). It is chemically designed as 4-[(4-methyl-1-piperazinyl)methyl]- N-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]benzamidine methanesulfonate, with a molecular formula of C 29H 31N 7O·CH 4SO 3. Its molecular weight is 589.72.


Chronic Myeloid Leukemia Gastrointestinal Stromal Tumor Blast Crisis Chronic Myeloid Leukemia Cell Central Nervous System Relapse 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of HaematologyRoyal Liverpool University HospitalLiverpoolUK