Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Steroid Sulfatase

  • Paul Foster
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5505-2

Synonyms

Definition

Steroid sulfatase (STS) is an enzyme which is virtually ubiquitous throughout the human body, and its activity is implicated in a range of physiological processes and pathological conditions. Its prime responsibility is for the hydrolysis of alkyl (e.g., dehydroepiandrosterone sulfate (DHEAS)) and aryl steroid sulfates (e.g., estrone sulfate (E1S)) and therefore plays an essential role in regulating the formation of steroids such as DHEA and E1 which can be converted to biologically active steroids (e.g., androstenediol (Adiol) and estradiol (E2)).

Characteristics

The activity of STS was first discovered in rat liver microsomes. Now it is known to be active in a plethora of tissue types, including testis, ovary, placenta, skin, lung, brain, and bone. Therefore, it is thought to be found in small quantities throughout the body. It is a member of a superfamily of 12 different mammalian sulfatases. The...

Keywords

Estrone Sulfate Dehydroepiandrosterone Sulfate Malignant Breast Tissue Steroid Sulfatase Human Endometrial Stromal Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

References

  1. Foster PA, Newman SP, Chander SK et al (2006) In vivo efficacy of STX213, a second-generation steroid sulfatase inhibitor, for hormone-dependent breast cancer therapy. Clin Cancer Res 12:5543–5549CrossRefPubMedGoogle Scholar
  2. Reed MJ, Purohit A, Woo LWL et al (2005) Steroid sulfatase: molecular biology, regulation, and inhibition. Endocr Rev 26:171–202CrossRefPubMedGoogle Scholar
  3. Stanway SJ, Purohit A, Woo LW et al (2006) Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor. Clin Cancer Res 1:1585–1592CrossRefGoogle Scholar

See Also

  1. (2012) Progestogens. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p. 2994. doi: 10.1007/978-3-642-16483-5_4757Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Endocrinology and Metabolic Medicine, Imperial College Faculty of MedicineSt. Mary’s HospitalLondonUK