Steroid sulfatase (STS) is an enzyme which is virtually ubiquitous throughout the human body, and its activity is implicated in a range of physiological processes and pathological conditions. Its prime responsibility is for the hydrolysis of alkyl (e.g., dehydroepiandrosterone sulfate (DHEAS)) and aryl steroid sulfates (e.g., estrone sulfate (E1S)) and therefore plays an essential role in regulating the formation of steroids such as DHEA and E1 which can be converted to biologically active steroids (e.g., androstenediol (Adiol) and estradiol (E2)).
The activity of STS was first discovered in rat liver microsomes. Now it is known to be active in a plethora of tissue types, including testis, ovary, placenta, skin, lung, brain, and bone. Therefore, it is thought to be found in small quantities throughout the body. It is a member of a superfamily of 12 different mammalian sulfatases. The...
KeywordsEstrone Sulfate Dehydroepiandrosterone Sulfate Malignant Breast Tissue Steroid Sulfatase Human Endometrial Stromal Cell
- (2012) Progestogens. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p. 2994. doi: 10.1007/978-3-642-16483-5_4757Google Scholar