Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Stem Cell Telomeres

  • Eiso Hiyama
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5493-2



Telomeres are guanine-rich tandem DNA repeats that cap the ends of eukaryotic chromosomes. Their primary function is to prevent chromosomal degradation, fusions, and instability. During cell division, telomeres shorten as a result of the incomplete replication of linear chromosomes. The slow rate of cell turnover in stem cell compartments means a longer period of telomere length stability in stem cells versus somatic cells. Nevertheless, stem cell telomeres do gradually shorten with age.


Human telomeres consist of tandem repetitive arrays of the hexameric sequence TTAGGG, with overall telomere sizes ranging from ∼15 kb at birth down to <5 kb in senescence cells or in some chronic disease states. The end of telomere forms a 3′ overhang of the G-rich strand, which is generated by the postreplicative processing of the C-rich strand and folds back into the duplex...


Stem Cell Telomere Length Aplastic Anemia Replicative Senescence Short Telomere 
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  1. Hiyama E, Hiyama K (2007) Telomere and telomerase in stem cells. Br J Cancer 96:1020–1024CrossRefPubMedPubMedCentralGoogle Scholar
  2. Shay JW, Zou Y, Hiyama E et al (2001) Telomerase and cancer. Hum Mol Genet 10:677–685CrossRefPubMedGoogle Scholar
  3. Vulliamy T, Marrone A, Goldman F et al (2001) The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature 413:432–435CrossRefPubMedGoogle Scholar
  4. Watson JD (1972) Origin of concatemeric T7 DNA. Nat New Biol (Lond) 239:197–201CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Natural Science Center for Basic Research and Development, Department of Pediatric Surgery, Hiroshima University HospitalHiroshima UniversityHiroshimaJapan