Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Stem Cell Plasticity

  • Malcolm R. Alison
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5492-2

Synonyms

Definition

Stem cell plasticity refers to the ability of some stem cells to give rise to cell types, formerly considered outside their normal repertoire of differentiation for the location where they are found. Included under this umbrella title is often the process of “transdifferentiation,” the conversion of one differentiated cell type into another, and metaplasia, the conversion of one tissue type into another. From the point of view of this essay, some metaplasias have a clinical significance because they predispose individuals to the development of cancer. Circulating bone marrow-derived cells (BMDCs) that usually generate all blood cell lineages can switch cell lineage commitment and contribute to the regeneration of several damaged non-hematopoietic tissues, and some carcinomas may even have their origins in BMDCs. The bone marrow origin of some tumor stromal cells and vasculature is now widely acknowledged, but since this pathway was...

Keywords

Basal Cell Carcinoma Atrophic Gastritis Gastric Gland Malleable Stem Cell Stem Cell Plasticity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Alison MR, Poulsom R, Otto WR et al (2003) Plastic adult stem cells: will they graduate from the school of hard knocks? J Cell Sci 116:599–603CrossRefPubMedGoogle Scholar
  2. Alison MR, Lovell MJ, Direkze NC et al (2006) Stem cell plasticity and tumour formation. Eur J Cancer 42:1247–1256CrossRefPubMedGoogle Scholar
  3. Burkert J, Wright NA, Alison MR (2006) Stem cells and cancer: an intimate relationship. J Pathol 209:287–297CrossRefPubMedGoogle Scholar
  4. Houghton J, Wang TC (2005) Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers. Gastroenterology 128:1567–1578CrossRefPubMedGoogle Scholar
  5. Slack JMW (2007) Metaplasia and transdifferentiation: from pure biology to the clinic. Nat Rev Mol Cell Biol 8:369–378CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Centre for Diabetes and Metabolic Medicine, Queen Barts and the London School of Medicine and DentistryInstitute of Cell and Molecular ScienceLondonUK