Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Stem Cell Markers

  • Gail M. Seigel
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5490-2

Definition

Stem cell markers are molecules used for the identification of unspecialized, undifferentiated cells and, in the case of malignancy, presumptive cancer stem cells.

Characteristics

There is increasing evidence that subpopulations of neoplastic cells demonstrate heterogeneity with respect to proliferation, differentiation, and expression of cellular proteins characteristic of stem cells. Subpopulations of cells that express stem cell markers that can also be shown to contribute to tumor progression and resistance to chemotherapy are termed cancer stem cells. Cancer stem cells are found in very small subpopulations within tumors, in the range of 0.1–1 % of the total cell number. Microscopically, cancer stem cells outwardly appear the same as any other tumor cell. Therefore, in order to identify these rare subpopulations, a number of stem cell markers have been identified and developed as a means of distinguishing stem-like cells from other cells within a cancer population....

Keywords

Stem Cell Cancer Stem Cell Stem Cell Marker Side Population Side Population Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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See Also

  1. (2012) Daughter cells. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1061. doi:10.1007/978-3-642-16483-5_1520Google Scholar
  2. (2012) Cancer stem cells. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 626. doi:10.1007/978-3-642-16483-5_815Google Scholar
  3. (2012) Cluster of differentiation (CD) molecules. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 885. doi:10.1007/978-3-642-16483-5_1225Google Scholar
  4. (2012) High mobility group. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1694. doi:10.1007/978-3-642-16483-5_2729Google Scholar
  5. (2012) Hoechst-33342 dye. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1718. doi:10.1007/978-3-642-16483-5_2785Google Scholar
  6. (2012) Lymph node metastases. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2116. doi:10.1007/978-3-642-16483-5_3444Google Scholar
  7. (2012) Pluripotency. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2930. doi:10.1007/978-3-642-16483-5_4637Google Scholar
  8. (2012) Pou transcription factors. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2966. doi:10.1007/978-3-642-16483-5_4697Google Scholar
  9. (2012) Self-renewal. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3359. doi:10.1007/978-3-642-16483-5_5226Google Scholar
  10. (2012) Stem cell factor. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3508. doi:10.1007/978-3-642-16483-5_5487Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Center for Hearing and DeafnessUniversity at BuffaloBuffaloUSA