v-Src (or viral Src) is a 60 kDa protein encoded by the oncogenic retrovirus, Rous sarcoma virus. The protein derives its name from its ability to induce sarcomas in experimental animals and malignantly transform cells in tissue culture. c-Src, or cellular Src, is the normal cellular progenitor of v-Src. c-Src is non- or weakly transforming when overexpressed in tissue culture cells. Both v- and c-Src are cytoplasmic tyrosine kinases that transfer phosphate from ATP to tyrosine residues within specific protein substrates. The resulting phosphotyrosine either conformationally activates the enzymatic activity of the recipient molecule or functions as a docking site for other molecules that transmit growth signals to the nucleus in a chain of events involving multiple phosphorylation and binding reactions. c-Src contains a carboxy-terminal region that maintains the molecule in a mostly inactive state. In v-Src, this 12-amino acid...
KeywordsFocal Adhesion Kinase Rous Sarcoma Virus Epidermal Growth Factor Receptor Family Cytoplasmic Tyrosine Kinase Fatty Acid Modification
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