Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Src

  • Sarah J. Parsons
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5464-2

Synonyms

Definition

v-Src (or viral Src) is a 60 kDa protein encoded by the oncogenic retrovirus, Rous sarcoma virus. The protein derives its name from its ability to induce sarcomas in experimental animals and malignantly transform cells in tissue culture. c-Src, or cellular Src, is the normal cellular progenitor of v-Src. c-Src is non- or weakly transforming when overexpressed in tissue culture cells. Both v- and c-Src are cytoplasmic tyrosine kinases that transfer phosphate from ATP to tyrosine residues within specific protein substrates. The resulting phosphotyrosine either conformationally activates the enzymatic activity of the recipient molecule or functions as a docking site for other molecules that transmit growth signals to the nucleus in a chain of events involving multiple phosphorylation and binding reactions. c-Src contains a carboxy-terminal region that maintains the molecule in a mostly inactive state. In v-Src, this 12-amino acid...

Keywords

Focal Adhesion Kinase Rous Sarcoma Virus Epidermal Growth Factor Receptor Family Cytoplasmic Tyrosine Kinase Fatty Acid Modification 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Abram CL, Courtneidge SA (2000) Src family tyrosine kinases and growth factor signaling. Exp Cell Res 254:1–13PubMedCrossRefGoogle Scholar
  2. Belsches-Jablonski AP, Demory ML, Parsons JT et al (2005) The Src pathway as a therapeutic strategy. Drug Discov Today: Ther Strateg 2:313–321CrossRefGoogle Scholar
  3. Ishizawar R, Parsons SJ (2004) c-Src and cooperating partners in human cancer. Cancer Cell 6:209–214PubMedCrossRefGoogle Scholar
  4. Thomas SM, Brugge JS (1997) Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 13:513–609PubMedCrossRefGoogle Scholar

See Also

  1. (2012) Glioblastoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1554. doi:10.1007/978-3-642-16483-5_2421Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.University of VirginiaCharlottevilleUSA