Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Ting Ling Lo
  • Graeme R. Guy
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5459-2



Sprouty (Spry) proteins are a family of endogenous proteins that negatively regulate the ERK/MAP kinase (ERK/MAPK) signaling pathway (Fig. 1) that is activated by receptor tyrosine kinases (RTKs).


Tyrosine Phosphorylation Lung Tumor Gastrointestinal Stromal Tumor Synovial Sarcoma Fibroblast Growth Factor Signaling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.


  1. Kim HJ, Bar-Sagi D (2004) Modulation of signaling by Sprouty: a developing story. Nat Rev Mol Cell Biol 5:441–450CrossRefPubMedGoogle Scholar
  2. Lo TL, Fong CW, Yusoff P et al (2006) Sprouty and cancer: the first terms report. Cancer Lett 242:141–150CrossRefPubMedGoogle Scholar
  3. Mason JM, Morrison DJ, Basson MA et al (2006) Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling. Trends Cell Biol 16:45–54CrossRefPubMedGoogle Scholar
  4. Shaw AT, Meissner A, Dowdle JA et al (2007) Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes Dev 21:694–707CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Signal Transduction LaboratoryInstitute of Molecular and Cell BiologySingaporeSingapore