Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Snail Transcription Factors

  • Amparo Cano
  • M. Angela Nieto
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5389-3

Synonyms

  • Additional synonyms for Snail1: Snail: SnR (chick), SNAILH (human), and Sna.

  • Additional synonyms for Snail2: Slug, hSlug (human), Xslug (Xenopus), Slugh (mouse), and Slu.

  • Snail3: Smuc

  • Human symbols for Snail1 and Snail2: SNAI1 and SNAI2.

  • Snail-like and SNAILP both refer to a human-specific Snail1 retrogene inserted in chromosome 2.

Definition

Snail genes are zinc finger transcriptional regulators of the Snail gene superfamily that participate in developmental and pathological epithelial-mesenchymal transition (EMT) processes. Snail1 was initially characterized as a potent repressor of E-cadherin, a major anti-invasive molecule in carcinomas. Snail1 is thus proposed as a potent inductor of tumor invasion, a process that frequently occurs associated with EMT. Besides E-cadherin repression, Snail1-mediated EMT requires the set in motion of a complex genetic program leading to the downregulation of additional epithelial gene markers, the upregulation of mesenchymal and migratory...

Keywords

Hepatocyte Growth Factor Nuclear Export Signal SNAIL1 Expression Snail Protein Snail Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. De Craene B, Berx G (2013) Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer 13:97–110CrossRefPubMedGoogle Scholar
  2. Díaz-López A, Moreno-Bueno G, Cano A (2014) Role of microRNA in epithelial to mesenchymal transition and metastasis and clinical perspectives. Cancer Manag Res 6:205–216PubMedPubMedCentralGoogle Scholar
  3. Nieto MA (2002) The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol 3:155–166CrossRefPubMedGoogle Scholar
  4. Nieto MA (2011) The ins and outs of the epithelial to mesenchymal transition in health and disease. Annu Rev Cell Dev Biol 27:347–376CrossRefPubMedGoogle Scholar
  5. Nieto MA, Cano A (2012) The epithelial-mesenchymal transition under control: global programs to regulate epithelial plasticity. Semin Cancer Biol 22:361–368CrossRefPubMedGoogle Scholar
  6. Peinado H, Olmeda D, Cano A (2007) Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 7:415–428CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Departamento de BioquímicaFacultad de Medicina, UAM, Instituto de Investigaciones Biomédicas “Alberto Sols” CSIC-UAM IdiPAZMadridSpain
  2. 2.Instituto de Neurociencias de Alicante CSIC-UMHSant Joan d’AlacantSpain