Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Snail Transcription Factors

  • Amparo Cano
  • M. Angela Nieto
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5389-3


  • Additional synonyms for Snail1: Snail: SnR (chick), SNAILH (human), and Sna.

  • Additional synonyms for Snail2: Slug, hSlug (human), Xslug (Xenopus), Slugh (mouse), and Slu.

  • Snail3: Smuc

  • Human symbols for Snail1 and Snail2: SNAI1 and SNAI2.

  • Snail-like and SNAILP both refer to a human-specific Snail1 retrogene inserted in chromosome 2.


Snail genes are zinc finger transcriptional regulators of the Snail gene superfamily that participate in developmental and pathological epithelial-mesenchymal transition (EMT) processes. Snail1 was initially characterized as a potent repressor of E-cadherin, a major anti-invasive molecule in carcinomas. Snail1 is thus proposed as a potent inductor of tumor invasion, a process that frequently occurs associated with EMT. Besides E-cadherin repression, Snail1-mediated EMT requires the set in motion of a complex genetic program leading to the downregulation of additional epithelial gene markers, the upregulation of mesenchymal and migratory...


Hepatocyte Growth Factor Nuclear Export Signal SNAIL1 Expression Snail Protein Snail Gene 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Departamento de BioquímicaFacultad de Medicina, UAM, Instituto de Investigaciones Biomédicas “Alberto Sols” CSIC-UAM IdiPAZMadridSpain
  2. 2.Instituto de Neurociencias de Alicante CSIC-UMHSant Joan d’AlacantSpain