Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Tamotsu Takeuchi
  • Mutsuo Furihata
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5337-2



Skeletrophin is one of three ubiquitin ligases, the substrate of which is a cytoplasmic region of Notch ligands and positively regulates ligand-dependent Notch activation. The gene maps to human chromosome position 1p36.32–33, where tumor suppressor factors for neuroendocrine tumors are encoded. Although at least six alternative splicing forms have been found in the public database, the major human product, which is expressed in many tissues, is composed of 999 amino acids and is approximately 110 kDa. Skeletrophin is localized in the cytoplasm and is widely expressed in various adult tissues, with particularly strong expression in the skeletal muscle, heart, and brain tissue. There are also alternative splicing forms expressed specifically in the brain and forms expressed specifically in the developing brain.


Skeletrophin has two mib/herc2 domains, a ZZ domain, ankyrin...


Hepatocyte Growth Factor Neuroendocrine Tumor Ubiquitin Ligase Myeloma Cell Bone Marrow Stromal Cell 
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  1. Koo BK, Yoon KJ, Yoo KW et al (2005) Mind bomb-2 is an E3 ligase for Notch ligand. J Biol Chem 280:22335–22342CrossRefPubMedGoogle Scholar
  2. Takeuchi T, Heng HH, Ye CJ et al (2003) Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma. Am J Pathol 163:1395–1404CrossRefPubMedPubMedCentralGoogle Scholar
  3. Takeuchi T, Adachi Y, Ohtsuki Y (2005a) Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma. Am J Pathol 166:1817–1826CrossRefPubMedPubMedCentralGoogle Scholar
  4. Takeuchi T, Adachi Y, Ohtsuki Y (2005b) Skeletrophin, a novel RING molecule controlled by the chromatin remodeling complex, is downregulated in malignant melanoma. DNA Cell Biol 24:339–344CrossRefPubMedGoogle Scholar
  5. Takeuchi T, Adachi Y, Sonobe H et al (2006) A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion. Oncogene 25:7059–7069CrossRefPubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of PathologyKochi Medical SchoolKochiJapan