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Sjögren Syndrome

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

  • 61 Accesses

Synonyms

Dry eye syndrome; Dry mouth syndrome; Keratoconjunctivitis sicca; KCS; Sicca complex; Sicca syndrome; Xerophthalmia; Xerostomia

Definition

Sjögren syndrome is a chronic, progressive autoimmune disorder that primarily affects the exocrine glands. The classic signs and symptoms include enlargement of the parotid and lacrimal glands, with mucosal dryness manifested by dry mouth (xerostomia) and dry eyes (xerophthalmia) (keratoconjunctivitis sicca). Lymphocytic infiltrates replace the functional epithelium, which results in decreased exocrine secretions (exocrinopathy).

Numerous features suggest an immunologic etiology. Patients demonstrate hypergammaglobulinemia and have several types of autoantibodies, such as the rheumatoid factor (RF), antinuclear antibodies (ANA, i.e., autoantibody against a nuclear substance), Ro/SSA and/or La/SSB, and antibodies to the salivary duct epithelium.

Characteristics

Sjögren syndrome is named after the Swedish ophthalmologist Henrik Sjögren....

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References

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See Also (part 1)

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See Also (part 2)

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Authors and Affiliations

  1. Division of Allergy-Immunology-Rheumatology, Department of Internal Medicine, Lin Shin Hospital, Taichung, Taiwan

    Pei-Lun Chou

  2. Department of Medicine, Institute of Immunology, Chung Shan Medical University, Taichung, Taiwan

    Gregory J. Tsay

Authors
  1. Pei-Lun Chou
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  2. Gregory J. Tsay
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Correspondence to Pei-Lun Chou .

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  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Chou, PL., Tsay, G.J. (2014). Sjögren Syndrome. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_5333-2

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