Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Sjögren Syndrome

  • Pei-Lun Chou
  • Gregory J. Tsay
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5333-2

Synonyms

Definition

Sjögren syndrome is a chronic, progressive autoimmune disorder that primarily affects the exocrine glands. The classic signs and symptoms include enlargement of the parotid and lacrimal glands, with mucosal dryness manifested by dry mouth (xerostomia) and dry eyes (xerophthalmia) (keratoconjunctivitis sicca). Lymphocytic infiltrates replace the functional epithelium, which results in decreased exocrine secretions (exocrinopathy).

Numerous features suggest an immunologic etiology. Patients demonstrate hypergammaglobulinemia and have several types of autoantibodies, such as the rheumatoid factor (RF), antinuclear antibodies (ANA, i.e., autoantibody against a nuclear substance), Ro/SSA and/or La/SSB, and antibodies to the salivary duct epithelium.

Characteristics

Sjögren syndrome is named after the Swedish ophthalmologist Henrik Sjögren....

Keywords

Salivary Gland Primary Biliary Cirrhosis Malt Lymphoma Chimeric Antigen Receptor Sicca Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Carbone A, Glogghini A (2000) Pathological features of lymphoid proliferations of the salivary glands: lymphoepithelial sialadenitis versus low-grade B-cell lymphoma of the malt type. Ann Otol Rhinol Laryngol 109:1170–1175PubMedCrossRefGoogle Scholar
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See Also (part 1)

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See Also (part 2)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Division of Allergy-Immunology-Rheumatology, Department of Internal MedicineLin Shin HospitalTaichungTaiwan
  2. 2.Department of MedicineInstitute of Immunology, Chung Shan Medical UniversityTaichungTaiwan