Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Basal Cell Carcinoma

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_529-2

Definition

Nonmelanoma skin cancers are the most common malignant neoplasms in the USA, representing one third of all cancers diagnosed every year. Basal cell carcinoma (BCC) represents 75 % of nonmelanoma skin cancers and has an estimated annual incidence of more than 700,000 cases in the USA outnumbering squamous cell carcinoma (SCC) 4–1. Over half a million BCCs are diagnosed in the USA annually, outnumbering squamous cell carcinoma (SCC) 4–1. The US average annual incidence of BCC in whites is currently 191 per 100,000 and is increasing at a rate of 3–7 % per year. The peak incidence of BCC occurs in the seventh decade of life and is rare in children.

Characteristics

Basal cell carcinoma has multiple distinctive clinical forms, and these clinical subtypes can often be correlated with histologic subtypes. BCC is protean in its manifestations. For this reason, biopsy for histologic confirmation is necessary. The various clinical forms of BCC include nodular, morpheaform, and...

Keywords

Basal Cell Carcinoma Xeroderma Pigmentosum Invasive Squamous Cell Carcinoma Nonmelanoma Skin Cancer Excisional Surgery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Arndt KA, LeBoit PE, Robinson JK (eds) (1996) Cutanous medicine and surgery. W.B. Saunders Company, PhiladelphiaGoogle Scholar
  2. Gailani MR, Leffell DJ, Zeigler A et al (1996) Relationship between sunlight exposure and key genetic alterations in basal cell carcinoma. J Natl Cancer Inst 88:349–354CrossRefPubMedGoogle Scholar
  3. Johnson TM, Rowe DE, Nelson BR et al (1992) Squamous cell carcinoma of the skin (excluding lip and oral mucosa). J Am Acad Dermatol 26:467–484CrossRefPubMedGoogle Scholar
  4. Lo JS, Snow SN, Reizner GT et al (1991) Metastatic basal cell carcinoma: report of twelve cases with a review of the literature. J Am Acad Dermatol 24:715–719CrossRefPubMedGoogle Scholar

See Also

  1. (2012) Basal Cell Nevus Syndrome. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 345–346. doi: 10.1007/978-3-642-16483-5_530Google Scholar
  2. (2012) Broder Histological Classification. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 571. doi: 10.1007/978-3-642-16483-5_737Google Scholar
  3. (2012) Cockayne Syndrome. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 890. doi: 10.1007/978-3-642-16483-5_1246Google Scholar
  4. (2012) Erythema. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1313. doi: 10.1007/978-3-642-16483-5_1993Google Scholar
  5. (2012) Mohs Micrographic Surgery. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2354. doi: 10.1007/978-3-642-16483-5_3807Google Scholar
  6. (2012) Morpheaform. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2372. doi: 10.1007/978-3-642-16483-5_3833Google Scholar
  7. (2012) Nevus. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2513. doi: 10.1007/978-3-642-16483-5_4061Google Scholar
  8. (2012) Radiation Therapy. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3144. doi: 10.1007/978-3-642-16483-5_4907Google Scholar
  9. (2012) Ultraviolet Light. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3841. doi: 10.1007/978-3-642-16483-5_6101Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Jorge R. Toro
    • 1
  • Rasha S. Hamouda
    • 2
  • Sherri Bale
    • 2
  1. 1.National Institutes of HealthBethesdaUSA
  2. 2.GeneDxRockvilleUSA