Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Shark Cartilage

  • Aditya Bardia
  • Charles L. Loprinzi
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5283-3

Definition

A dietary supplement derived from cartilage obtained from sharks, commonly hammerhead (Sphyrna lewini) and dogfish (Squalus acanthias) sharks.

Characteristics

Shark cartilage is a popular dietary supplement that traditionally has been proclaimed to be able to prevent and/or treat established cancer. In the early part of the twenty-first century, it has been one of the ten most common dietary supplements used among cancer patients. It has been suggested that the widespread popularity of this product has partly contributed to an increase in shark fishing, with a resultant sharp, ≥75 %, decline in the world shark population in the past 15 years.

Shark cartilage is available as a capsule (taken orally), powder (for oral use when mixed with juice or as an enema), and also as an intravenous preparation. The recommended doses can vary from 500 mg to several grams per day. The adverse effects are predominantly gastrointestinal, such as nausea, abdominal pain, and diarrhea, and even...

Keywords

Dietary Supplement Endothelial Cell Apoptosis Cancer Clinical Trial Shark Cartilage Shark Population 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Lane IW, Comac L (1992) Sharks don’t get cancer: how shark cartilage could save your life. Avery Publishing Group, Garden City ParkGoogle Scholar
  2. Latreille J, Batist G, Laberge F et al (2003) Phase I/II trial of the safety and efficacy of AE-941 (Neovastat) in the treatment of non-small-cell lung cancer. Clin Lung Cancer 4(4):231–236CrossRefPubMedGoogle Scholar
  3. Lee A, Langer R (1983) Shark cartilage contains inhibitors of tumor angiogenesis. Science 221:1185–1187CrossRefPubMedGoogle Scholar
  4. Loprinzi CL, Levitt R, Barton DL, North Central Cancer Treatment Group et al (2005) Evaluation of shark cartilage in patients with advanced cancer: a North Central Cancer Treatment Group trial. Cancer 104(1):176–182CrossRefPubMedGoogle Scholar
  5. Miller DR, Anderson GT, Stark JJ et al (1998) Phase I/II trial of the safety and efficacy of shark cartilage in the treatment of advanced cancer. J Clin Oncol 16:3649–3655PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Attending Physician, Massachusetts General Hospital Cancer CenterAssistant Professor, Harvard Medical SchoolBostonUSA
  2. 2.Department of OncologyMayo ClinicRochesterUSA