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Encyclopedia of Cancer pp 1–5Cite as

BARD1

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Synonyms

BARD-1; BRCA1 associated Ring domain (gene/protein) 1

Definition

BARD1 codes for a protein that forms a functional heterodimer with the breast cancer predisposition gene product BRCA1. The BRCA1-BARD1 complex has E3 ubiquitin ligase activity, but not the respective monomers. The specific targets of the BRCA1-BARD1 ubiquitin ligase partially explain the tumor suppressor functions of BARD1 and BRCA1. BRCA1-independent functions are attributed to BARD1, based on its role as inducer of p53-dependent apoptosis. Cancer cells and human cytotrophoblasts express isoforms of BARD1 that lack various functional regions, are void of tumor suppressor functions, and have tumor promoting activities (Irminger-Finger et al. 2015).

Characteristics

The tumor suppressor BARD1 was originally identified as a protein binding to the BRCA1 gene product, BRCA1. The stability of both proteins depends on their interaction via their N-terminal RING finger domains. BRCA1 depends on binding to BARD1 for...

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References

  • Bosse KR, Diskin SJ, Cole KA, Wood AC, Schnepp RW, Norris G, Nguyen LB, Jagannathan J, Laquaglia M, Winter C et al (2012) Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity. Cancer Res 72:2068

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Capasso M, Devoto M, Hou C, Asgharzadeh S, Glessner JT, Attiyeh EF, Mosse YP, Kim C, Diskin SJ, Cole KA et al (2009) Common variations in BARD1 influence susceptibility to high-risk neuroblastoma. Nat Genet 41:718–723

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Feki A, Jefford CE, Durand P, Harb J, Lucas H, Krause KH, Irminger-Finger I (2004) BARD1 expression during spermatogenesis is associated with apoptosis and hormonally regulated. Biol Reprod 71:1614–1624

    Article  CAS  PubMed  Google Scholar 

  • Feki A, Jefford CE, Berardi P, Wu JY, Cartier L, Krause KH, Irminger-Finger I (2005) BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase. Oncogene 24:3726–3736

    Article  CAS  PubMed  Google Scholar 

  • Irminger-Finger I, Soriano JV, Vaudan G et al. (1998) In vitro repression of Brca1-associated RING domain gene, Bard1, induces phenotypic changes in mammary epithelial cells. J Cell Biol 143:1329–1339

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Irminger-Finger I, Leung WC, Li J, Dubois-Dauphin M, Harb J, Feki A, Jefford CE, Soriano JV, Jaconi M, Montesano R, Krause KH (2001) Identification of BARD1 as mediator between proapoptotic stress and p53-dependent apoptosis. Mol Cell 8:1255–1266

    Article  CAS  PubMed  Google Scholar 

  • Irminger-Finger I, Ratajska M, Pilyugin M (2016) New concepts on BARD1: regulator of BRCA pathways and beyond. Int J Biochem Cell Biol 72:1–17

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  • Li M, Yu X (2013) Function of BRCA1 in the DNA damage response is mediated by ADP-ribosylation. Cancer Cell 23:693–704

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li L, Cohen M, Wu J, Sow MH, Nikolic B, Bischof P, Irminger-Finger I (2007a) Identification of BARD1 splice-isoforms involved in human trophoblast invasion. Int J Biochem Cell Biol 39:1659–1672

    Article  CAS  PubMed  Google Scholar 

  • Li L, Ryser S, Dizin E, Pils D, Krainer M, Jefford CE, Bertoni F, Zeillinger R, Irminger-Finger I (2007b) Oncogenic BARD1 isoforms expressed in gynecological cancers. Cancer Res 67:11876–11885

    Article  CAS  PubMed  Google Scholar 

  • McCarthy EE, Celebi JT, Baer R et al. (2003) Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability. Mol Cell Biol 23:5056–5063

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ryser S, Dizin E, Jefford C, Delaval B, Christodoulidou A, Gagos S, Krause KH, Birnbaum D, Irminger-Finger I (2009) Distinct roles of BARD1 isoforms in mitosis: full length BARD1 mediates Aurora B degradation, cancer-associated BARD1? Scaffolds Aurora B and BRCA2. Cancer Res 69:1125–1134

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Molecular Gynecology and Obstetrics Laboratory, Department of Gynecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland

    Irmgard Irminger-Finger

Authors
  1. Irmgard Irminger-Finger
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Corresponding author

Correspondence to Irmgard Irminger-Finger .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2014 Springer-Verlag Berlin Heidelberg

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Cite this entry

Irminger-Finger, I. (2014). BARD1. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_526-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_526-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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