Skip to main content

Serine-Threonine Kinase Receptor-Associated Protein

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

Synonyms

hMAWD: Human MAPK activator with WD repeats; STRAP; Unrip: unr-interacting protein

Definition

STRAP is a 39 kDa protein of WD40 family involved in probable chaperoning function during the formation of multiprotein complexes shown to be active in the transforming growth factor-β (TGF-β) receptor signaling network and U-rich small nuclear ribonucleoprotein (U snRNP) assembly. Oncogenic STRAP is upregulated in human cancers and may be involved in tumor progression.

Characteristics

STRAP was first cloned from mouse embryonic cDNA library while searching for novel proteins that bind the cytoplasmic region of TGF-β type I receptor (TβRI) using yeast two-hybrid screening. Later it was found that STRAP could associate with both type I and type II (TβRII) serine-threonine kinase receptors. Southern blot analyses demonstrate that STRAP is evolutionarily conserved from yeast to mammals. The importance of this conservation was revealed when STRAP knockout mice were generated using the...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  • Buess M, Terracciano L, Reuter J et al (2004) STRAP is a strong predictive marker of adjuvant chemotherapy benefit in colorectal cancer. Neoplasia 6(6):813–820

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Datta P, Moses H (2000) STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling. Mol Cell Biol 20(9):3157–3167

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Datta P, Chytil A, Gorska A et al (1998) Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling. J Biol Chem 273(52):34671–34674

    Article  CAS  PubMed  Google Scholar 

  • Halder S, Anumanthan G, Maddula R et al (2006) Oncogenic function of a novel WD-domain protein, STRAP, in human carcinogenesis. Cancer Res 66(12):6156–6166

    Article  CAS  PubMed  Google Scholar 

  • Seong H, Jung H, Choi H et al (2005) Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein. J Biol Chem 280(52):42897–42908

    Article  CAS  PubMed  Google Scholar 

See Also

  • (2012) APAF-1. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 231. doi:10.1007/978-3-642-16483-5_344

    Google Scholar 

  • (2012) Oncogenic Viruses. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2623. doi:10.1007/978-3-642-16483-5_4225

    Google Scholar 

  • (2012) SMAD. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3440. doi:10.1007/978-3-642-16483-5_5360

    Google Scholar 

  • (2012) Tumor Necrosis Factor-α. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3800. doi:10.1007/978-3-642-16483-5_6041

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Nilesh D. Kashikar .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag Berlin Heidelberg

About this entry

Cite this entry

Kashikar, N.D., Datta, P.K. (2015). Serine-Threonine Kinase Receptor-Associated Protein. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_5259-2

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-27841-9_5259-2

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics