Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Sentinel Lymph Node

  • Omgo E. Nieweg
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5242-4

Synonyms

Definition

A sentinel lymph node is a lymph node upon which the primary tumor drains directly.

Characteristics

General Anatomy and Physiology of the Lymphatic System

Lymphatic capillaries are 10–50 μm in diameter, consist of a single endothelial layer with a discontinuous membrane, and are supported by collagen filaments. They are filled with lymph fluid originating from the interstitial space due to an osmotic pressure gradient and fluctuating intraluminal pressures. These intraluminal pressures are caused by lymphatic flow that is generated by lymph formation, contractions of the vessel wall, and external pressure. Lymph fluid absorbed by lymphatic capillaries drains into larger collecting lymphatic vessels. Such lymphatic vessels drain into marginal and medullar sinuses located between germinal centers within a lymph node. These centers contain large numbers of phagocytic cells. A plexus within the lymph node drains to the efferent...

Keywords

Sentinel Node Sentinel Node Biopsy Lymphatic Vessel Lymph Edema Penile Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Kroon BK, Horenblas S, Lont AP, Tanis PJ, Gallee MP, Nieweg OE (2005) Patients with penile carcinoma benefit from immediate resection of clinically occult lymph node metastases. J Urol 173:816–819PubMedCrossRefGoogle Scholar
  2. Morton DL, Wen DR, Wong JH, Economou JS, Cagle LA, Storm FK et al (1992) Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg 127:392–399PubMedCrossRefGoogle Scholar
  3. Morton DL, Thompson JF, Cochran AJ, Mozzillo N, Nieweg OE, Roses DF et al (2014) Final trial report of sentinel-node biopsy versus nodal observation in melanoma. N Engl J Med 370:599–609PubMedCentralPubMedCrossRefGoogle Scholar
  4. Nieweg OE, Tanis PJ, Kroon BBR (2001) The definition of a sentinel node. Ann Surg Oncol 9:538–541CrossRefGoogle Scholar
  5. Tanis PJ, Nieweg OE, Valdés Olmos RA, Kroon BBR (2001) Anatomy and physiology of lymphatic drainage of the breast from the perspective of sentinel node biopsy. J Am Coll Surg 192:399–409PubMedCrossRefGoogle Scholar
  6. Van der Ploeg IMC, Nieweg OE, Van Rijk MC, Valdés Olmos RA, Kroon BBR (2008) Axillary recurrence after a tumour-negative sentinel node biopsy in breast cancer patients: a systematic review and meta-analysis of the literature. Eur J Surg Oncol 34:1277–1284PubMedCrossRefGoogle Scholar

See Also

  1. (2012) Lymphatic System. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer, Berlin Heidelberg, p 2120. doi:10.1007/978-3-642-16483-5_3450Google Scholar
  2. (2012) Lymphoscintigraphy. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer, Berlin Heidelberg, p 2124. doi:10.1007/978-3-642-16483-5_3464Google Scholar
  3. (2012) Radio-Labeled Tracer. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer, Berlin Heidelberg, p 3150. doi:10.1007/978-3-642-16483-5_4912Google Scholar
  4. (2012) Second-Tier/Third-Tier Lymph Node. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer, Berlin Heidelberg, p 3348. doi:10.1007/978-3-642-16483-5_5196Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Melanoma Institute AustraliaNorth SydneyAustralia