Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Sentinel Lymph Node

  • Omgo E. Nieweg
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5242-4



A sentinel lymph node is a lymph node upon which the primary tumor drains directly.


General Anatomy and Physiology of the Lymphatic System

Lymphatic capillaries are 10–50 μm in diameter, consist of a single endothelial layer with a discontinuous membrane, and are supported by collagen filaments. They are filled with lymph fluid originating from the interstitial space due to an osmotic pressure gradient and fluctuating intraluminal pressures. These intraluminal pressures are caused by lymphatic flow that is generated by lymph formation, contractions of the vessel wall, and external pressure. Lymph fluid absorbed by lymphatic capillaries drains into larger collecting lymphatic vessels. Such lymphatic vessels drain into marginal and medullar sinuses located between germinal centers within a lymph node. These centers contain large numbers of phagocytic cells. A plexus within the lymph node drains to the efferent...


Sentinel Node Sentinel Node Biopsy Lymphatic Vessel Lymph Edema Penile Cancer 
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See Also

  1. (2012) Lymphatic System. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer, Berlin Heidelberg, p 2120. doi:10.1007/978-3-642-16483-5_3450Google Scholar
  2. (2012) Lymphoscintigraphy. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer, Berlin Heidelberg, p 2124. doi:10.1007/978-3-642-16483-5_3464Google Scholar
  3. (2012) Radio-Labeled Tracer. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer, Berlin Heidelberg, p 3150. doi:10.1007/978-3-642-16483-5_4912Google Scholar
  4. (2012) Second-Tier/Third-Tier Lymph Node. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer, Berlin Heidelberg, p 3348. doi:10.1007/978-3-642-16483-5_5196Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Melanoma Institute AustraliaNorth SydneyAustralia