Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Securin

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5214-2

Synonyms

Definition

Securin is a 22 kDa protein that is crucial for the stability of the cells’ genome. By preventing premature sister-chromatid separation during mitosis, securin is involved in the regulation of accurate cell cycle progression.

Characteristics

The proto-oncogene PTTG was first isolated from rat pituitary tumor cells. The human homologue of PTTG, securin(hPTTG1), was found to be overexpressed in Jurkat T cells (human lymphoma T cell line) and in leukocytes from patients with different types of hematopoietic neoplasms or myelodysplastic syndromes. High levels of securin protein expression have been reported for various other tumors, including tumors of the pituitary gland, adrenal gland, kidney, endometrium, uterus, and ovary as well as esophageal and colorectal cancer. Hence, securin has been implicated in...

Keywords

Esophageal Squamous Cell Carcinoma TCF4 Protein Cohesin Protein Noncycling Cell Elevated Cell Proliferation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bradshaw C, Kakar SS (2007) Pituitary tumor transforming gene: an important gene in normal cellular functions and tumorigenesis. Histol Histopathol 22:219–226PubMedGoogle Scholar
  2. Hlubek F, Pfeiffer S, Budczies J et al (2006) Securin (hPTTG1) expression is regulated by beta-catenin/TCF in human colorectal carcinoma. Br J Cancer 94:1672–1677PubMedPubMedCentralGoogle Scholar
  3. Malumbres M, Barbacid M (2001) To cycle or not to cycle: a critical decision in cancer. Nat Rev Cancer 1:222–231CrossRefPubMedGoogle Scholar
  4. Tfelt-Hansen J, Kanuparthi D, Chattopadhyay N (2006) The emerging role of pituitary tumor transforming gene in tumorigenesis. Clin Med Res 4:130–137CrossRefPubMedPubMedCentralGoogle Scholar
  5. Zhou C, Liu S, Zhou X et al (2005) Overexpression of human pituitary tumor transforming gene (hPTTG), is regulated by beta-catenin/TCF pathway in human esophageal squamous cell carcinoma. Int J Cancer 113:891–898CrossRefPubMedGoogle Scholar

See Also

  1. (2012) Anaphase-Promoting Complex. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 168. doi: 10.1007/978-3-642-16483-5_253Google Scholar
  2. (2012) BFGF. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 388. doi: 10.1007/978-3-642-16483-5_596Google Scholar
  3. (2012) Double-Strand Break DNA Repair. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 1158-1159. doi: 10.1007/978-3-642-16483-5_1721Google Scholar
  4. (2012) EGF. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1211. doi: 10.1007/978-3-642-16483-5_1824Google Scholar
  5. (2012) HGF. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1693. doi: 10.1007/978-3-642-16483-5_2710Google Scholar
  6. (2012) Ku70. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1963. doi: 10.1007/978-3-642-16483-5_3248Google Scholar
  7. (2012) Matrix Metalloproteinase 2. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 2182-2183. doi: 10.1007/978-3-642-16483-5_3557Google Scholar
  8. (2012) Nude Mice. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2584. doi: 10.1007/978-3-642-16483-5_4172Google Scholar
  9. (2012) P53. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2747. doi: 10.1007/978-3-642-16483-5_4331Google Scholar
  10. (2012) Sister-Chromatids. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3418. doi: 10.1007/978-3-642-16483-5_5329Google Scholar
  11. (2012) Transactivation Domain. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3748. doi: 10.1007/978-3-642-16483-5_5894Google Scholar
  12. (2012) Transforming Growth Factor Alpha. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3758. doi: 10.1007/978-3-642-16483-5_5915Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of PathologyLudwig-Maximilians-University of MunichMunichGermany