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Secreted Protein Acidic and Rich in Cysteine

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  • First Online:
Encyclopedia of Cancer

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Synonyms

BM-40; Osteonectin; SPARC

Definition

Secreted protein acidic and rich in cysteine (SPARC) belongs to a group of nonstructural proteins of the extracellular matrix (ECM), termed matricellular proteins, which modulate interactions between cells and their environment. It is expressed in developing and remodeling tissues and regulates cell attachment, deposition of ECM, matrix mineralization, and angiogenesis.

Characteristics

SPARC is a counter-adhesive protein that induces cell rounding, inhibits cell spreading, and mediates focal adhesion disassembly and the reorganization of actin stress fibers. In several cell types, it delays cell cycle in G1phase. It is the main noncollagenous component of the bone, where binding of SPARC to collagen can induce deposition of calcium. However, inhibition of hydroxylapatite crystallization suggests that SPARC prevents matrix mineralization rather than inducing it. SPARC also regulates the production, assembly, and organization of ECM, and...

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References

  • Chlenski A, Cohn SL (2010) Modulation of matrix remodeling by SPARC in neoplastic progression. Semin Cell Dev Biol 21(1):55-65

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  • Framson PE, Sage EH (2004) SPARC and tumor growth: where the seed meets the soil? J Cell Biochem 92:679–690

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  • Lane TF, Sage EH (1994) The biology of SPARC, a protein that modulates cell-matrix interactions. FASEB J 8:163–173

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See Also

  • (2012) AKT. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 115. doi: 10.1007/978-3-642-16483-5_163

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  • (2012) Basic Fibroblast Growth Factor. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 349. doi: 10.1007/978-3-642-16483-5_539

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  • (2012) EF-Hand. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 1210-1211. doi: 10.1007/978-3-642-16483-5_1818

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  • (2012) Matricellular Proteins. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2182. doi: 10.1007/978-3-642-16483-5_3550

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  • (2012) Microenvironment. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2296. doi: 10.1007/978-3-642-16483-5_3720

    Google Scholar 

  • (2012) SMAD. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3440. doi: 10.1007/978-3-642-16483-5_5360

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  • (2012) TGF-β. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3661. doi: 10.1007/978-3-642-16483-5_5753

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pediatrics, Section of Hematology/Oncology, University of Chicago, Chicago, IL, USA

    Alexandre Chlenski & Susan L. Cohn

Authors
  1. Alexandre Chlenski
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  2. Susan L. Cohn
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Corresponding author

Correspondence to Alexandre Chlenski .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Chlenski, A., Cohn, S.L. (2014). Secreted Protein Acidic and Rich in Cysteine. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_5212-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_5212-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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