Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

S-Phase Damage-Sensing Checkpoints

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5140-2

Definition

Cell cycle checkpoints function by sensing DNA damage and transmitting a signal that results in arrest at defined stages of the cycle. The S phase “checkpoint” halts cells during the DNA synthetic period in response to DNA damage (DNA damage responses) and is somewhat different from other checkpoints in two ways. First, in the classic paradigm, cell cycle progression is halted at various discrete points in the cycle (e.g., in G1, at the G2/M transition, and during mitosis), and cells are usually arrested for many hours prior to reentry into the cycle. In contrast, the S phase damage-sensing pathway arrests cell cycle progression for only an hour or so and seemingly at any position within the S phase; therefore, it is difficult to think of it as a checkpoint per se (although we will refer to it as such in this review). As more is learned about the molecular basis of all of the checkpoints, it is becoming clear that each may have multiple targets. Thus, the underlying...

Keywords

Fanconi Anemia Ataxia Telangiectasia Mutate Ataxia Telangiectasia Ataxia Telangiectasia Nijmegen Breakage Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Forsburg SL (2004) Eukaryotic MCM proteins: beyond replication initiation. Microbiol Mol Biol Rev 68:109–131CrossRefPubMedPubMedCentralGoogle Scholar
  2. Lee H, Larner JM, Hamlin JL (1997) A p53-independent damage-sensing mechanism that functions as a checkpoint at the G1/S transition in Chinese hamster ovary cells. Proc Natl Acad Sci U S A 94:526–531CrossRefPubMedPubMedCentralGoogle Scholar
  3. Lehmann AR (2005) The role of SMC proteins in the responses to DNA damage. DNA Repair (Amst) 4:309–314CrossRefGoogle Scholar
  4. Pichierri P, Rosselli F (2004) The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways. EMBO J 23:1178–1187CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Therapeutic Radiology and OncologyUniversity of Virginia School of MedicineCharlottesvilleUSA
  2. 2.Department of Biochemistry and Molecular GeneticsUniversity of Virginia School of MedicineCharlottesvilleUSA