Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Ron Receptor

  • Megan N. Thobe
  • Susan E. Waltz
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5124-4



Cell-surface receptor tyrosine kinases regulate critical signaling pathways and elicit a variety of important biological responses that contribute to tumorigenesis. The Ron receptor tyrosine kinase has been implicated in a number of human cancers. Ron belongs to a family of receptor tyrosine kinases that includes the Met proto- oncogene. The Ron ortholog in the mouse is also referred to as stem cell-derived tyrosine kinase ( Stk), while the chicken counterpart encodes c-sea. The human Ron gene is located on chromosome 3p21.3 and contains 20 exons with a transcript length of 4,531 base pairs (bps) and a translation length of 1,400 residues. The murine counterpart contains 75 % identity to the human protein and is located on chromosome 9. The mouse Ron gene contains 19 exons with a transcript length of 4,710 bps and 1,378 residues. A comparison of the genomic organization of the human and mouse Ron is depicted in Fig. 1.


Mouse Mammary Tumor Virus Tyrosine Kinase Domain Lung Adenoma Mouse Mammary Tumor Virus Promoter Stomach Cancer Cell Line 
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  1. Angeloni D, Danilkovitch-Miagkova A, Ivanov SV (2000) Gene structure of the human receptor tyrosine kinase RON and mutation analysis in lung cancer samples. Genes Chromosomes Cancer 29:147–156CrossRefPubMedGoogle Scholar
  2. Danilkovitch-Miagkova A (2003) Oncogenic signaling pathways activated by RON receptor tyrosine kinase. Curr Cancer Drug Targets 3:31–40CrossRefPubMedGoogle Scholar
  3. Santoro MM, Collesi C, Grisendi S et al (1996) Constitutive activation of the RON gene promotes invasive growth but not transformation. Mol Cell Biol 16(12):7072–7083CrossRefPubMedPubMedCentralGoogle Scholar
  4. Wang MH, Yao HP, Zhou YQ (2006) Oncogenesis of RON receptor tyrosine kinase: a molecular target for malignant epithelial cancers. Acta Pharmacol Sin 6:641–650CrossRefGoogle Scholar
  5. Zinser GM, Leonis MA, Toney K et al (2006) Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation. Cancer Res 66(24):11967–11974CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.University of Cincinnati College of MedicineCincinnatiUSA
  2. 2.Cancer and Cell BiologyUniversity of Cincinnati College of Medicine, Cincinnati Veteran’s Administration HospitalCincinnatiUSA