Living reference work entry
Cell-surface receptor tyrosine kinases regulate critical signaling pathways and elicit a variety of important biological responses that contribute to tumorigenesis. The Ron receptor tyrosine kinase has been implicated in a number of human cancers. Ron belongs to a family of receptor tyrosine kinases that includes the Met proto- oncogene. The Ron ortholog in the mouse is also referred to as stem cell-derived tyrosine kinase ( Stk), while the chicken counterpart encodes c-sea. The human Ron gene is located on chromosome 3p21.3 and contains 20 exons with a transcript length of 4,531 base pairs (bps) and a translation length of 1,400 residues. The murine counterpart contains 75 % identity to the human protein and is located on chromosome 9. The mouse Ron gene contains 19 exons with a transcript length of 4,710 bps and 1,378 residues. A comparison of the genomic organization of the human and mouse Ron is depicted in Fig. 1.
KeywordsMouse Mammary Tumor Virus Tyrosine Kinase Domain Lung Adenoma Mouse Mammary Tumor Virus Promoter Stomach Cancer Cell Line
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