Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Retinoid Receptor Cross-Talk

  • Athanasios G. PapavassiliouEmail author
  • Michalis V. Karamouzis
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5073-3

Synonyms

Definition

The process of intercellular retinoid receptor activation by another activated transcription factor or the alternate. It may also be considered as the cooperation among different signal transduction pathways in various normal and pathological states, whereby activation of retinoid receptors enhances the activity of other transcription factors in the absence of direct activation, thus leading in positive or negative regulation of specific target genes.

Characteristics

Retinoids

Retinoids comprise a group of structural and functional derivatives of vitamin A that are considered physiological regulators of a plethora of essential biological processes, including embryonic development, vision, reproduction, differentiation, proliferation, and apoptosis. Pharmacologically, they have been shown to suppress carcinogenesisin a wide gamut of tissues (e.g., skin, respiratory...

Keywords

Nuclear Receptor Superfamily Retinoid Receptor Transcriptional Cofactor Retinoic Acid Response Element Retinoid Acid Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

References

  1. Altucci L, Leibowitz MD, Ogilvie KM, de Lera AR, Gronemeyer H (2007) RAR and RXR modulation in cancer and metabolic disease. Nat Rev Drug Discov 6:793–810CrossRefPubMedGoogle Scholar
  2. Bushue N, Wan YJ (2010) Retinoid pathway and cancer therapeutics. Adv Drug Deliv Rev 62:1285–1298CrossRefPubMedPubMedCentralGoogle Scholar
  3. Karamouzis MV, Papavassiliou AG (2005) Retinoid receptors cross talk in respiratory epithelium cancer chemoprevention. Trends Mol Med 11:10–16CrossRefPubMedGoogle Scholar
  4. Karamouzis MV, Sotiropoulou-Bonikou G, Vandoros G, Varakis I, Papavassiliou AG (2004) Differential expression of retinoic acid receptor beta (RARβ) and AP-1 transcription factor in normal, premalignant and malignant human laryngeal tissues. Eur J Cancer 40:761–773CrossRefPubMedGoogle Scholar
  5. Khuri FR, Lee J, Lippman SM, Kim ES, Cooper JS, Benner SE, Winn R, Pajak TFB, Williams B, Shenouda G, Hodson I, Fu K, Shin DM, Vokes EE, Feng L, Goepfert H, Hong WK (2006) Randomized phase III trial of low-dose isotretinoin for prevention of second primary tumors in stage I and II head and neck cancer patients. J Natl Cancer Inst 98:441–450CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Athanasios G. Papavassiliou
    • 1
    Email author
  • Michalis V. Karamouzis
    • 1
  1. 1.Department of Biological Chemistry, Medical SchoolUniversity of AthensGoudiGreece