Retinoid Receptor Cross-Talk
The process of intercellular retinoid receptor activation by another activated transcription factor or the alternate. It may also be considered as the cooperation among different signal transduction pathways in various normal and pathological states, whereby activation of retinoid receptors enhances the activity of other transcription factors in the absence of direct activation, thus leading in positive or negative regulation of specific target genes.
Retinoids comprise a group of structural and functional derivatives of vitamin A that are considered physiological regulators of a plethora of essential biological processes, including embryonic development, vision, reproduction, differentiation, proliferation, and apoptosis. Pharmacologically, they have been shown to suppress carcinogenesisin a wide gamut of tissues (e.g., skin, respiratory...
KeywordsNuclear Receptor Superfamily Retinoid Receptor Transcriptional Cofactor Retinoic Acid Response Element Retinoid Acid Receptor
- Khuri FR, Lee J, Lippman SM, Kim ES, Cooper JS, Benner SE, Winn R, Pajak TFB, Williams B, Shenouda G, Hodson I, Fu K, Shin DM, Vokes EE, Feng L, Goepfert H, Hong WK (2006) Randomized phase III trial of low-dose isotretinoin for prevention of second primary tumors in stage I and II head and neck cancer patients. J Natl Cancer Inst 98:441–450CrossRefPubMedGoogle Scholar