Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Retinoblastoma Protein, Biological and Clinical Functions

  • Helen Dimaras
  • Brenda L. Gallie
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5069-9

Synonyms

Definition

pRB is the protein product of the retinoblastoma tumor suppressor gene, RB1. Its biological functions include controlling the cell cycle, preserving genome integrity, mediating differentiation, as well as protecting cells from apoptosis. Mutation of RB1 resulting in functional inactivation of pRB leads to the childhood retinal tumor retinoblastoma and predisposes to osteosarcoma and other cancers. Defective function of pRB or its pathway also contributes to tumor progression in many other cancer types.

Characteristics

The RB1 Gene Encodes the pRB Protein

The RB1 gene contains 27 exons and is located on human chromosome 13q14.2 (NCBI Entrez Gene ID: 5925). The product of RB1is the 110 kDa retinoblastoma susceptibility protein (pRB), composed of 928 amino...

Keywords

Cell Cycle Control Hereditary Retinoblastoma Pocket Domain Retinoblastoma Tumor Suppressor Gene NCBI Entrez Gene Database 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Coschi CH, Martens AL, Ritchie K et al (2010) Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor suppressive. Genes Dev 24:1351–1363CrossRefPubMedPubMedCentralGoogle Scholar
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.The Hospital for Sick Children, Department of Ophthalmology and Vision ScienceThe University of TorontoTorontoCanada