Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

RET

  • Oliver Gimm
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5065-2

Definition

Rearranged during transfection: RET is the abbreviation for a gene that was found to be rearranged during transfection studies of NIH-3T3 cells with human lymphoma DNA. It is a receptor tyrosine kinase, for which the ligand is glial cell line-derived neurotrophic factors (GDNF). It was originally detected as an oncogenic version from a T-cell lymphoma.

Characteristics

RETis located on chromosome sub-band 10q11.2 and consists of at least 21 exons. Alternative polyadenylation sites and alternative splicing result in different transcript sizes. RET splice variants contain the first 19 exons, followed by distinct 3′ ends. These variants produce three protein isoforms that have 9 (RET9), 51 (RET51), or 43 (RET43) distinct amino acids at their C termini. The gene encodes for a transmembrane tyrosine kinase receptor. The first ten exons, and maybe part of exon 11, encode the extracellular domain; exon 11 encodes the transmembrane domain, while the remaining exons encode the...

Keywords

Papillary Thyroid Carcinoma Medullary Thyroid Carcinoma Multiple Endocrine Neoplasia Type Enteric Nervous System Enteric Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Airaksinen MS, Holm L, Hätinen T (2006) Evolution of the GDNF family ligands and receptors. Brain Behav Evol 68:181–190CrossRefPubMedGoogle Scholar
  2. Asai N, Jijiwa M, Enomoto A et al (2006) RET receptor signaling: dysfunction in thyroid cancer and Hirschsprung’s disease. Pathol Int 56:164–172CrossRefPubMedGoogle Scholar
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  4. Santoro M, Melillo RM, Fusco A (2006) RET/PTC in papillary thyroid carcinoma: European journal of endocrinolgy prize lecture. Eur J Endocrinol 155:645–653CrossRefPubMedGoogle Scholar
  5. Zbuk KM, Eng C (2007) Cancer phenomics: RET and PTEN as illustrative models. Nat Rev Cancer 7:35–45CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of SurgeryUniversity HospitalLinköpingSweden