Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Relaxin

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5019-2

Definition

Relaxin is a small peptidehormone comprising two subunits, together about 6,000 Da in size. Relaxin has been identified as a locally produced factor in a number of key tissues, such as the thyroid gland, gastrointestinal tract, heart, uterus, and lung. Relaxin is known to function in cells by activating a G-protein-coupled receptor on the cell surface called LGR7 or RXFP1 (relaxin family peptide 1). The main functions of relaxin are linked to uniquely mammalian traits such as lactation, viviparity, and post-reproductive survival.

Characteristics

Relaxin is a small peptidehormone belonging to the insulin family of hormones and growth factors. Its major sources in the body are in women the corpus luteum of the premenopausal ovary and the placenta and in men the prostate gland. In humans, unlike most other mammals, there are two genes for relaxin, RLN1 and RLN2. The products of these genes appear to behave identically in most bioassay systems. Since the RLN1gene product is...

Keywords

Thyroid Cancer LNCaP Prostate Cancer Cell Line Relaxin Receptor Specific Physiological Process Endometrium Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bani D (1997) Relaxin and breast cancer. Bull Cancer 84:179–182PubMedGoogle Scholar
  2. Bathgate RA, Hsueh AJ, Ivell R et al (2006) International Union of Pharmacology. Recommendations for the nomenclature of receptors for relaxin family peptides. Pharmacol Rev 58:7–31CrossRefPubMedGoogle Scholar
  3. Binder C, Simon A, Binder L et al (2004) Elevated concentrations of serum relaxin are associated with metastatic disease in breast cancer patients. Breast Cancer Res Treat 87:157–166CrossRefPubMedGoogle Scholar
  4. Ivell R, Einspanier A (2002) Relaxin peptides are new global players. Trends Endocrinol Metab 13:343–348CrossRefPubMedGoogle Scholar
  5. Silvertown JD, Summerlee AJS, Klonisch T (2003) Relaxin-like peptides in cancer. Int J Cancer 107:513–519CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.School of BioSciences and School of Veterinary Medicine and ScienceUniversity of NottinghamNottinghamUK