Regulatory T Cells
Regulatory T (Treg) cells are a specialized subpopulation of T cells that are capable of suppressing immune responses and thereby inducing immune tolerance to self and nonself. Suppressive T cells were initially described in the early 1970s and 1980s and their suppressive function was implicated in tumor-induced suppressive immunity. However, due to a lack of phenotypic markers for defining these cells, there was extensive skepticism about their existence in vivo. In 1995, Sakaguchi and colleagues showed that CD25, the interleukin-2 (IL-2) receptor α chain, could serve as a phenotypic marker for CD4+ suppressor T cells or CD4+ Treg cells. Over the past few years, several distinct subsets of Treg cells have been identified, which include (i) naturally occurring CD4+ CD25+ FoxP3+ Treg cells; (ii) antigen-induced CD4+ Treg cells such as antigen-specific CD4+ CD25+ FoxP3+Treg cells, IL-10-producing Tr1 cells, and TGF-β-producing Th3 cells;...
KeywordsTreg Cell Suppressive Function Treg Cell Function Treg Cell Population Treg Cell Number
- (2012) Cytotoxic T lymphocytes. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1058. doi:10.1007/978-3-642-16483-5_1501Google Scholar
- (2012) Interleukin-2. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1892. doi:10.1007/978-3-642-16483-5_3097Google Scholar
- (2012) T-cell receptor. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3621. doi:10.1007/978-3-642-16483-5_5701Google Scholar