Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Regeneration

  • Claudia Mitchell
  • Chantal Desdouets
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5011-2

Synonyms

Definition

Regeneration is the recovery of cell mass of a given organ following cell loss. The balance between cell loss and cell renewal is tightly controlled. When this balance is altered, inappropriate cell growth occurs leading to the development of cancer.

Characteristics

Under normal circumstances, the processes of tissue regeneration or homeostasis are tightly regulated by several pathways to prevent excessive or inappropriate cell growth. Two kinds of cell types can participate in tissue regeneration: stem cells, which are multipotent cells that can both self-renew and give rise to more differentiated cells, and terminally differentiated cells, which are normally quiescent but are able to proliferate upon a stimulus. Some tissues regenerate from their pool of stem cells, like the intestine and the skin, and others, like the liver and the kidney, regenerate from fully differentiated cells that constitute these organs.

One classic...

Keywords

Adenomatous Polyposis Coli Hedgehog Signaling Biliary Epithelial Cell Tumorigenic Process Tissue Renewal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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See Also

  1. (2012) Axin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 324. doi: 10.1007/978-3-642-16483-5_496Google Scholar
  2. (2012) Beta-Catenin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 385. doi: 10.1007/978-3-642-16483-5_889Google Scholar
  3. (2012) ERK/MAP Kinase. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 1308. doi: 10.1007/978-3-642-16483-5_1988Google Scholar
  4. (2012) Gli. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 1552. doi: 10.1007/978-3-642-16483-5_2418Google Scholar
  5. (2012) Glycogen synthase kinase-3. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 1570. doi: 10.1007/978-3-642-16483-5_2448Google Scholar
  6. (2012) Ligands. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 2040. doi: 10.1007/978-3-642-16483-5_3352Google Scholar
  7. (2012) Liver cancer. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 2063. doi: 10.1007/978-3-642-16483-5_3393Google Scholar
  8. (2012) P53. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 2747. doi: 10.1007/978-3-642-16483-5_4331Google Scholar
  9. (2012) Patched. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 2792. doi: 10.1007/978-3-642-16483-5_4403Google Scholar
  10. (2012) Senescence. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 3370. doi: 10.1007/978-3-642-16483-5_5236Google Scholar
  11. (2012) Ubiquitin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 3825. doi: 10.1007/978-3-642-16483-5_6083Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Institut CochinUniversité Paris Descartes, CNRSParisFrance