Carbonyl reduction of aldehydes, ketones, and quinones to their corresponding hydroxy derivatives plays an important role in the phase I metabolism of many endogenous (biogenic aldehydes, steroids, prostaglandins, reactive lipid peroxidation products) and xenobiotic (pharmacologic drugs, carcinogens, toxicants) compounds (Xenobiotics).
From the pharmacologist’s point of view, carbonyl reduction is of significance in various inactivation processes of drugs bearing a carbonyl group. The carbinols formed may retain therapeutic potency, thus prolonging the pharmacodynamic effect of the parent drug, or, in some instances, a compound gains activity through carbonyl reduction. From the toxicologist’s point of view, carbonyl reduction plays an important role in the toxification of drugs such as daunorubicin and doxorubicin (Adriamycin), whereas numerous reports corroborate the concept...
KeywordsAldose Reductase Glycyrrhetinic Acid Carbonyl Reductase Smokeless Tobacco User Carbonyl Reduction
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