Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Ras Association Domain Family 1

  • Ashraf Dallol
  • Farida Latif
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4953-2



The Ras-association domain family 1 ( RASSF1) is a member of a new family of RAS or RAS-like small GTPases effectors. There are five other bonafide RASSF members all harboring a C-terminus Ras-association (RA) and Salvador/RASSF/Hippo (SARAH) domains. Genome databases have classified two proteins as RASSF7 and RASSF8 where the RA domain is located at the N-terminus. RASSF1also exists in at least seven isoforms generated by alternative splicing or promoter usage. Only the longest isoform, isoform A, harbors an additional cysteine-rich diacylglycerol (DAG or C1) lipid-binding domain. The RA domain shares a similar structure with the highly characterized Ras-binding protein, Raf. However, unlike Raf, RASSF1 and the other RASSF proteins lack catalytic domains, and they are more likely to function as adaptors to recruit additional proteins. The SARAH domain is thought to form a coiled-coil region that mediates homo- and heterotypic interactions with other SARAH...


Breast Cancer Risk Hippo Pathway Nipple Aspirate Fluid RASSF1A Methylation RASSF1A Promoter 
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© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Medical and Molecular Genetics, Institute of Biomedical ResearchUniversity of BirminghamBirminghamUK