Definition
Radiological response criteria attempt to provide objective measures of tumor response to therapy. They are widely used as surrogate endpoints in clinical trials of cytotoxic chemotherapy and novel therapeutic agents.
Characteristics
Historical Developments
The need for standardized and objective outcome criteria to measure response to anticancer treatment has been recognized for over 50 years. In 1960, the Eastern Cooperative Oncology Group proposed that objective measurement of tumor size should be used as an endpoint in the evaluation of cytotoxic chemotherapy, since killing tumor cells had been shown to reduce lesion dimensions.
These principles were first codified in the World Health Organization (WHO) document, published in 1979. In particular four categories of response to chemoradiotherapywere defined – complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD). While many early assessments of tumor size relied on clinical...
This is a preview of subscription content, log in via an institution.
References
Benjamin RS, Choi H, Macapinlac HA et al (2007) We should resist using RECIST, at least in GIST. J Clin Oncol 25:1760–1764
Dempsey MF, Condon BR, Hadley DM (2005) Measurement of tumor “size” in recurrent malignant glioma: 1D, 2D, or 3D? Am J Neuroradiol 26:770–776
Eisenhauer EA, Therasse P, Bogaerts J et al (2009) New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 45:228–247
Michaelis LC, Ratain MJ (2006) Measuring response in a post-RECIST world: from black and white to shades of grey. Nat Rev Cancer 6:409–414
Therasse P, Arbuck SG, Eisenhauer EA et al (2000) New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst 92:205–216
Zia MI, Siu MI, Pond GR et al (2005) Comparison of outcomes of phase II studies and subsequent randomized control studies using identical chemotherapeutic regimens. J Clin Oncol 23:6982–6991
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer-Verlag Berlin Heidelberg
About this entry
Cite this entry
O’Connor, J.P.B., Jayson, G.C., Jackson, A. (2015). Radiological Response Criteria. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_4919-2
Download citation
DOI: https://doi.org/10.1007/978-3-642-27841-9_4919-2
Received:
Accepted:
Published:
Publisher Name: Springer, Berlin, Heidelberg
Online ISBN: 978-3-642-27841-9
eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences