Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Autophagy

  • Amanda Schalk
  • Sven Thoms
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_487-3

Synonyms

Definition

Autophagy is the intracellular uptake of cytoplasm (proteins, nucleic acids, small molecules, whole organelles, etc.) into the lysosome and its subsequent degradation. Autophagy is a constitutive as well as a stress-inducible process responsible for the degradation of the majority of cellular proteins.

Characteristics

The lysosomal uptake and degradation of proteins by autophagy can be found in virtually all eukaryotic cells. Autophagy is a homeostatic catabolic process by which long-lived cytosolic proteins and complexes (like ribosomes) are degraded and recycled. Unlike the ubiquitin-proteosome system of degradation, autophagy is able to degrade large protein aggregates and is the only pathway able to degrade whole organelles. Autophagy is regarded to be a largely nonselective bulk process, but it also exhibits selectivity during the biogenesis of the lysosome (import of lysosomal...

Keywords

Chronic Myelogenous Leukemia Tuberous Sclerosis Complex Phosphatidyl Ethanolamine Autophagosome Formation Autophagy Inhibition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bhutia SK et al (2013) Autophagy: Cancer’s Friend or Foe? Advances in Cancer Research 118:61–95CrossRefPubMedPubMedCentralGoogle Scholar
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See Also

  1. (2012) AKT. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 115. doi: 10.1007/978-3-642-16483-5_163Google Scholar
  2. (2012) AMPK. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 160. doi:10.1007/978-3-642-16483-5_244Google Scholar
  3. (2012) Autophagic Body. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 317. doi:10.1007/978-3-642-16483-5_484Google Scholar
  4. (2012) Autophagosome. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 317. doi:10.1007/978-3-642-16483-5_486Google Scholar
  5. (2012) Beclin 1. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 380. doi:10.1007/978-3-642-16483-5_576Google Scholar
  6. (2012) Chaperone. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 754. doi:10.1007/978-3-642-16483-5_1046Google Scholar
  7. (2012) Lysosome. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2128. doi:10.1007/978-3-642-16483-5_3472Google Scholar
  8. (2012) Microautophagy. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2292. doi:10.1007/978-3-642-16483-5_3711Google Scholar
  9. (2012) Peroxisome. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2820. doi:10.1007/978-3-642-16483-5_4472Google Scholar
  10. (2012) Proto-Oncogenes. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 3107–3108. doi:10.1007/978-3-642-16483-5_6656Google Scholar
  11. (2012) Rheb. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3302. doi:10.1007/978-3-642-16483-5_5096Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.University of Illinois at ChicagoChicagoUSA
  2. 2.University of GöttingenGöttingenGermany