Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

14-3-3 Proteins

  • Guri TzivionEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4813-3


Are abundant, highly conserved adaptor proteins of ~30 kDa found in all eukaryotes. Similar to the binding of SH2 domains to phosphorylated tyrosine residues, 14-3-3 proteins usually bind to their client protein via a phosphorylated Ser- or Thr-residue in a sequence-specific context (mode I: RSXpS/TP; mode II: RXXXpS/TXP with p indicating the phosphorylated residue and X any amino acid). 14-3-3 proteins assist in the stabilization of the client protein in either an active or inactive conformation. 14-3-3 proteins regulate a multitude of biological processes ranging from metabolic control to the regulation of apoptosis, cell cycle progression, and mitogenic signaling. One of the seven human 14-3-3 genes, 14-3-3σ/stratifin, is frequently epigenetically silenced in breast, lung, and prostate cancer and is discussed as a tumor suppressor gene.



Cell Cycle Prostate Cancer Cancer Research Biological Process Tumor Suppressor 
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© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Cancer Institute, Department of BiochemistryUniversity of Mississippi Medical CenterJacksonUSA