Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

14-3-3 Proteins

  • Guri Tzivion
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4813-3

Definition

Are abundant, highly conserved adaptor proteins of ~30 kDa found in all eukaryotes. Similar to the binding of SH2 domains to phosphorylated tyrosine residues, 14-3-3 proteins usually bind to their client protein via a phosphorylated Ser- or Thr-residue in a sequence-specific context (mode I: RSXpS/TP; mode II: RXXXpS/TXP with p indicating the phosphorylated residue and X any amino acid). 14-3-3 proteins assist in the stabilization of the client protein in either an active or inactive conformation. 14-3-3 proteins regulate a multitude of biological processes ranging from metabolic control to the regulation of apoptosis, cell cycle progression, and mitogenic signaling. One of the seven human 14-3-3 genes, 14-3-3σ/stratifin, is frequently epigenetically silenced in breast, lung, and prostate cancer and is discussed as a tumor suppressor gene.

Cross-References

Keywords

Cell Cycle Prostate Cancer Cancer Research Biological Process Tumor Suppressor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Cancer Institute, Department of BiochemistryUniversity of Mississippi Medical CenterJacksonUSA