Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Proteinase-Activated Receptor-3

  • Anke Rattenholl
  • Tobias Görge
  • Stefan W. Schneider
  • Martin Steinhoff
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4808-2

Synonyms

Definition

PAR3 is a G protein-coupled receptor which can be activated by thrombin (factor IIa). It consists of 374 amino acids (42 kDa) including the amino-terminal signal sequence and is highly expressed in megakaryocytes of the bone marrow. A lower expression is found in mature megakaryocytes, platelets, the heart, and the gut. The gene maps to 5q13.3 (gene name: F2RL2).

Characteristics

PAR3 is activated by specific proteolysis at the site LPIK38 ↓ T39FRGAP to expose the tethered ligand LPIK which binds to the second extracellular loop, thus activating the receptor. No synthetic peptides exist which are able to stimulate PAR3 in vitro, as observed with the other members of this receptor family. Distal to the thrombin cleavage site, there is a hirudin-like binding site located. This enables binding and concentration of thrombin at the cell surface, rendering PAR3a high-affinity receptor for thrombin....

Keywords

Renal Cell Carcinoma Renal Cell Cleavage Site Signal Sequence Synthetic Peptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Anke Rattenholl
    • 1
  • Tobias Görge
    • 2
  • Stefan W. Schneider
    • 3
  • Martin Steinhoff
    • 2
  1. 1.Applied Biotechnology Division, Department of Engineering and MathematicsBielefeldGermany
  2. 2.UCD Charles Institute of DermatologyUniversity College DublinBelfieldIreland
  3. 3.Hauttumorzentrum Mannheim (HTZM)Universitätsmedizn MannheimMannheimGermany