The proteasome is a large molecular proteolytic machine, responsible for most regulated protein degradation within cells. The proteasome functions, along with protein ubiquitination, within the ubiquitin-proteasome system (UPS), although there are also ubiquitin-independent functions of the proteasome.
The proteasome performs ATP-dependent protein degradation in the contexts of protein turnover, in quality control of misfolded proteins, and in the tight control of key regulatory proteins for important cellular processes. The proteasome can also perform more discrete, regulatory protease cleavages of target proteins, rather than degradation, modifying the activity of the cleaved protein. There is a...
KeywordsProteasomal Degradation Cancer Cachexia Skeletal Muscle Protein Regulatory Particle Hereditary Cancer Syndrome
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