Protease-Activated Receptor Family
Living reference work entry
The protease-activated receptors (PARs) are a group of seven transmembrane G protein-coupled receptors with a unique mechanism of activation. Most receptors are activated when the ligand binds to the ligand binding domain of that receptor. However, the different serine protease ligands that activate PAR will cleave the N-terminus of the receptor. This results in the formation of a new N-terminus peptide which acts as a tethered ligand that will now bind to the activation site of the receptor and cause irreversible activation of PAR (Fig. 1).
KeywordsBenign Prostatic Hyperplasia Pancreatic Cancer Cell Pancreatic Cancer Tissue Thrombin Receptor Pancreatic Ductal Carcinoma
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