Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Protease-Activated Receptor Family

  • G. J. Villares
  • M. Zigler
  • Bar-Eli Menashe
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4783-3

Definition

The protease-activated receptors (PARs) are a group of seven transmembrane G protein-coupled receptors with a unique mechanism of activation. Most receptors are activated when the ligand binds to the ligand binding domain of that receptor. However, the different serine protease ligands that activate PAR will cleave the N-terminus of the receptor. This results in the formation of a new N-terminus peptide which acts as a tethered ligand that will now bind to the activation site of the receptor and cause irreversible activation of PAR (Fig. 1).

Keywords

Benign Prostatic Hyperplasia Pancreatic Cancer Cell Pancreatic Cancer Tissue Thrombin Receptor Pancreatic Ductal Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Boire A, Covic L, Agarwal A et al (2005) PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Cell 120(3):303–313CrossRefPubMedGoogle Scholar
  2. Ikeda O, Egami H, Ishiko T et al (2003) Expression of proteinase-activated receptor-2 in human pancreatic cancer: a possible relation to cancer invasion and induction of fibrosis. Int J Oncol 22(2):295–300PubMedGoogle Scholar
  3. Kaushal V, Kohli M, Dennis RA et al (2006) Thrombin receptor expression is upregulated in prostate cancer. Prostate 66(3):273–282CrossRefPubMedGoogle Scholar
  4. Macfarlane SR, Seatter MJ, Kanke T et al (2001) Proteinase-activated receptors. Pharmacol Rev 53(2):245–282PubMedGoogle Scholar
  5. Tellez C, Bar-Eli M (2003) Role and regulation of the thrombin receptor (PAR-1) in human melanoma. Oncogene 22(20):3130–3137CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • G. J. Villares
    • 1
  • M. Zigler
    • 1
  • Bar-Eli Menashe
    • 1
  1. 1.Department of Cancer BiologyThe University of Texas, M.D. Anderson Cancer CenterHoustonUSA