Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Protease-Activated Receptor Family

  • G. J. Villares
  • M. Zigler
  • Bar-Eli Menashe
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4783-3


The protease-activated receptors (PARs) are a group of seven transmembrane G protein-coupled receptors with a unique mechanism of activation. Most receptors are activated when the ligand binds to the ligand binding domain of that receptor. However, the different serine protease ligands that activate PAR will cleave the N-terminus of the receptor. This results in the formation of a new N-terminus peptide which acts as a tethered ligand that will now bind to the activation site of the receptor and cause irreversible activation of PAR (Fig. 1).


Benign Prostatic Hyperplasia Pancreatic Cancer Cell Pancreatic Cancer Tissue Thrombin Receptor Pancreatic Ductal Carcinoma 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • G. J. Villares
    • 1
  • M. Zigler
    • 1
  • Bar-Eli Menashe
    • 1
  1. 1.Department of Cancer BiologyThe University of Texas, M.D. Anderson Cancer CenterHoustonUSA