Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Programmed Cell Death 4

  • Sachiko Matsuhashi
  • Iwata Ozaki
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4761-3



PDCD4/Pdcd4 is a tumor suppressor. This protein contains two MA-3 domains homologous to the M1 domain of eIF4G and nuclear localization signals. PDCD4/Pdcd4 exhibits multiple functions such as the regulation of protein synthesis, the controls of transcription, and the induction of apoptosis. The human gene maps to 10q24.


Human PDCD4 (H731) was first identified as a gene involved in the cell cycle. The human gene has also been isolated as a gene whose expression in lymphocytes was modulated by interleukins. The mouse gene (MA-3) was found to be upregulated during the induction of apoptosis, and the same gene (TIS) was downregulated by topoisomerase inhibitors such as etoposide and camptothecin. In chickens, Pdcd4 expression has been demonstrated to be controlled by the transcription factor myb. PDCD4/Pdcd4 is ubiquitously...


Huh7 Cell Smad Signaling Pathway PDCD4 Expression PDCD4 Protein PDCD4 Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Internal Medicine, Saga Medical SchoolSaga UniversitySagaJapan
  2. 2.Health Administration Center, Saga Medical SchoolSaga UniversitySagaJapan