Progestin is a synthetic progestogen that has progestinic effects similar to progesterone. Progesterone (4-pregnene-3,20-dione, P4) is an ovarian steroid hormone that plays a key role in the regulation of cell proliferation and differentiation in the female reproductive tract. Progesterone also regulates diverse biological effects in a broad range of tissues, even of the cardiovascular and the central nervous systems, and participates in the bone maintenance and regulation of thymic involution. Progesterone has also been implicated in the development and progression of breast cancer. Progestogen defines the category of hormone molecules (natural and synthetic) that act like progesterone in the uterus, and the term progestin has been generally used to refer to both a series of synthetic hormone molecules and progesterone. The generic term progestin refers to both progesterone and synthetic progestins.
The two most studied progesterone...