Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Autoantibodies

  • Marie-Claire Maroun
  • Félix Fernández Madrid
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_466-2

Definition

Autoantibodies are those antibodies to proteins, nucleic acids, carbohydrates, or lipids derived from the cells of the organism in which they were formed, recognized by the immune system as nonself. Cancer-associated autoantibodies are potential reagents for the early diagnosis and prognosis of cancer. Autoantibodies target molecules involved in signal transduction, cell cycle regulation, cell proliferation, and apoptosis; all of them are key processes in carcinogenesis. Molecular studies of antigen–antibody systems in cancer can also yield valuable mechanistic information on the carcinogenic process. The study of autoantibodies in cancer has broad implications for the discovery of molecular targets for drug therapy and for cancer biomarkers in general. Tumor-associated antigens (TAAs) and their corresponding antibodies can also be invaluable reagents in the selection of naturally immunogenic molecules as key targets for cancer immunotherapy.

Characteristics

Multiple studies...

Keywords

Breast Cancer cDNA Expression Library Autoantibody Profile Autoantibody Response Autoantibody Reactivity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Fernández Madrid F, Maroun M-C, Olivero OA, Long M, Azadeh Stark A, Grossman LI, Binder W, Dong J, Burke M, Nathanson SD, Zarbo R, Chitale D, Zeballos-Chávez R, Peebles C (2015) Autoantibodies in breast cancer sera are not epiphenomena and may participate in carcinogenesis. BMC Cancer 15:407CrossRefPubMedCentralGoogle Scholar
  2. Hanash S (2011) Harnessing the immune response for cancer detection. Cancer Epidemiol Biomarkers Prev 20:569–570CrossRefPubMedGoogle Scholar
  3. Iyer MK, Niknafs YS, Malik R et al (2015) The landscape of long noncoding RNAs in the human transcriptome. Nat Genet 47:199–208CrossRefPubMedPubMedCentralGoogle Scholar
  4. Sahin U, Tureci O, Schmitt H et al (1995) Human neoplasms elicit multiple specific immune responses in the autologous host. Proc Natl Acad Sci U S A 92:11810–11813CrossRefPubMedPubMedCentralGoogle Scholar
  5. Weinbeg RA (2014) Coming full circle-from endless complexity to simplicity and back again. Cell 157:267–271CrossRefGoogle Scholar

See Also

  1. (2012) Affinity-matured IgG response. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 100. doi:10.1007/978-3-642-16483-5_133Google Scholar
  2. (2012) Antigen-presenting cells. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 209–210. doi:10.1007/978-3-642-16483-5_321Google Scholar
  3. (2012) B-cell response. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 351. doi:10.1007/978-3-642-16483-5_557Google Scholar
  4. (2012) FcR. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1386. doi:10.1007/978-3-642-16483-5_2135Google Scholar
  5. (2012) Humoral immune response. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1760. doi:10.1007/978-3-642-16483-5_2865Google Scholar
  6. (2012) Immunoscreening cDNA expression libraries. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1831. doi:10.1007/978-3-642-16483-5_3009Google Scholar
  7. (2012) Major histocompatibility complex. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2137. doi:10.1007/978-3-642-16483-5_3500Google Scholar
  8. (2012) Medullary breast carcinoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2199. doi:10.1007/978-3-642-16483-5_3599Google Scholar
  9. (2012) Paraneoplastic syndromes. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 2784–2785. doi:10.1007/978-3-642-16483-5_4387Google Scholar
  10. (2012) Tolerance. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3723. doi:10.1007/978-3-642-16483-5_5853Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Internal Medicine, Division of RheumatologyWayne State UniversityDetroitUSA