Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Podoplanin

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4651-2

Synonyms

Definition

Human podoplanin is a type-1 transmembrane glycoprotein consisting of 162 amino acids, nine of which form the intracellular domain. The extracellular domain is extensively O-glycosylated. Depending on glycosylation, the molecular mass is between 36 and 45 kDa. Podoplanin is physiologically expressed in kidney podocytes, skeletal muscle, placenta, lung, heart, myofibroblasts of the breast and salivary glands, osteoblasts and mesothelial cells, and on the apical surface of alveolar type I cells. Occasionally, focal expression of podoplanin can be found in circumscribed areas of the basal layer of the human epidermis. Podoplanin is also expressed in lymphatic endothelium, but not in blood vessels. Pathological expression of podoplanin is observed in many human cancers, in particular squamous cell carcinomas.

Characteristics

In tumors, podoplanin is expressed by the cancer cells themselves, where it...

Keywords

Lymphatic Vessel Lymphatic Endothelial Cell Lymphatic Endothelium Podoplanin Expression Epithelial Canine Kidney Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Hantusch B, Kalt R, Krieger S et al (2007) Sp1/Sp3 and DNA-methylation contribute to basal transcriptional activation of human podoplanin in MG63 versus Saos-2 osteoblastic cells. BMC Mol Biol 8:20CrossRefPubMedPubMedCentralGoogle Scholar
  2. Martin-Villar E, Megias D, Castel S et al (2006) Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition. J Cell Sci 119:4541–4553CrossRefPubMedGoogle Scholar
  3. Schacht V, Dadras SS, Johnson LA et al (2005) Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol 166:913–921CrossRefPubMedPubMedCentralGoogle Scholar
  4. Wicki A, Christofori G (2007) The potential role of podoplanin in tumour invasion. Br J Cancer 96:1–5CrossRefPubMedGoogle Scholar
  5. Wicki A, Lehembre F, Wick N et al (2006) Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton. Cancer Cell 9:261–272CrossRefPubMedGoogle Scholar

See Also

  1. (2012) Carcinoma. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 657. doi:10.1007/978-3-642-16483-5_848Google Scholar
  2. (2012) Collective Cell Invasion. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 896. doi:10.1007/978-3-642-16483-5_1262Google Scholar
  3. (2012) Lyve-1. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2128. doi:10.1007/978-3-642-16483-5_3473Google Scholar
  4. (2012) Microspikes. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2308. doi:10.1007/978-3-642-16483-5_3733Google Scholar
  5. (2012) Outer Edge of the Tumor Mass. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2670. doi:10.1007/978-3-642-16483-5_4292Google Scholar
  6. (2012) Rho. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3302. doi:10.1007/978-3-642-16483-5_5099Google Scholar
  7. (2012) Sarcoma. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3335. doi:10.1007/978-3-642-16483-5_5161Google Scholar
  8. (2012) Single Cell Invasion. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3412. doi:10.1007/978-3-642-16483-5_5311Google Scholar
  9. (2012) Thrombotic Cancer Cell Emboli. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3682. doi:10.1007/978-3-642-16483-5_5797Google Scholar
  10. (2012) Tumor Progression. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3800. doi:10.1007/978-3-642-16483-5_6046Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Medical OncologyUniversity HospitalBaselSwitzerland
  2. 2.Department of BiomedicineUniversity of BaselBaselSwitzerland