Synonyms
Definition
Pleiotrophin (PTN) is an 18 kDa growth factor that has high affinity for heparin and together with midkine forms a family of structurally related heparin-binding growth factors. The two proteins share 45 % homology in their amino acid sequence and ten perfectly conserved cysteine residues. They also use the same receptors and share many biological activities, the best characterized being neural development and tumor growth.
Characteristics
PTN consists of 168 amino acids that are highly conserved across different species, such as human, mouse, rat, bovine, fish, chicken, frog, and insects. The cleavage of the 32 amino acids signal peptide leads to a secreted protein,...
Keywords
- Focal Adhesion Kinase
- Human Umbilical Vein Endothelial Cell
- Anaplastic Lymphoma Kinase
- LNCaP Cell
- Athymic Nude Mouse
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
Mikelis C, Koutsioumpa M, Papadimitriou E (2007) Pleiotrophin as a possible new target for angiogenesis-related diseases and cancer. Recent Pat Anticancer Drug Discov 2:175–186
Papadimitriou E, Mikelis C, Lampropoulou E, Koutsioumpa M, Theochari K, Tsirmoula S, Theodoropoulou C, Lamprou M, Sfaelou E, Vourtsis D, Boudouris P (2009) Roles of pleiotrophin in tumor growth and angiogenesis. Eur Cytokine Netw 20:180–190
Pantazaka E, Papadimitriou E (2012) PTN (pleiotrophin). Atlas Genet Cytogenet Oncol Haematol 16:821–837
Pantazaka E, Papadimitriou E (2014) Chondroitin Sulfate-cell membrane effectors as regulators of growth factor-mediated vascular and cancer cell migration. BBA - General Subjects, 1840:2643–2650
See Also
(2012) AKT. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 115. doi:10.1007/978-3-642-16483-5_163
(2012) Chondroitin sulfate. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 821–822. doi:10.1007/978-3-642-16483-5_1118
(2012) Glycosaminoglycans. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1570. doi:10.1007/978-3-642-16483-5_2453
(2012) Heparan sulfate proteoglycans. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1647. doi:10.1007/978-3-642-16483-5_2638
(2012) HOXA5 gene. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1739. doi:10.1007/978-3-642-16483-5_2820
(2012) Leukemia. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2005. doi:10.1007/978-3-642-16483-5_3322
(2012) Midkine. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2313. doi:10.1007/978-3-642-16483-5_3743
(2012) N-Syndecan. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2567. doi:10.1007/978-3-642-16483-5_5622
(2012) Pancreas. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 2762–2763. doi:10.1007/978-3-642-16483-5_7055
(2012) Receptor protein tyrosine phosphatase beta/zeta. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3198. doi:10.1007/978-3-642-16483-5_4979
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Papadimitriou, E. (2014). Pleiotrophin. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_4621-3
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DOI: https://doi.org/10.1007/978-3-642-27841-9_4621-3
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Publisher Name: Springer, Berlin, Heidelberg
Online ISBN: 978-3-642-27841-9
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