Definition
Platinum-refractory germ cell tumors (GCTs) are GCTs which no longer respond to cisplatin-based chemotherapy. Cisplatinum-refractory disease is defined as response or disease stabilization during, but disease progression within 4 weeks after cisplatin-based chemotherapy, whereas absolutely cisplatin-refractory disease refers to patients with progression during cisplatin-based treatment.
In a broader sense, multiply relapsed (≥3 recurrences) GCTs are also often referred to as treatment-refractory GCTs.
Characteristics
Today, approximately 70–80 % of all patients with metastatic germ cell cancer will achieve long-term cure after standard-dose, cisplatin-based combination chemotherapy, such as PEB (cisplatin, etoposide, bleomycin) or VIP (etoposide, ifosfamide, cisplatin). Patients relapsing after cisplatin-based first-line chemotherapy have a less...
Keywords
- Germ Cell Tumor
- Salvage Chemotherapy
- Germ Cell Cancer
- Lung Resistance Protein
- Xeroderma Pigmentosum Complementation Group
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
Albers P, Ganz A, Hannig E et al (2000) Salvage surgery of chemorefractory germ cell tumors with elevated tumor markers. J Urol 164:381–384
Kollmannsberger C, Nichols C, Bokemeyer C (2006) Recent advances in management of patients with platinum-refractory testicular germ cell tumors. Cancer 106:1217–1226
Looijenga LH, Oosterhuis JW (2002) Pathobiology of testicular germ cell tumors: views and news. Anal Quant Cytol Histol 24:263–279
Mayer F, Honecker F, Looijenga LH et al (2003) Towards an understanding of the biological basis of response to cisplatin-based chemotherapy in germ-cell tumors. Ann Oncol 14:825–832
Porcu P, Bhatia S, Einhorn LH (2000) Results of treatment after relapse from high-dose chemotherapy in germ cell tumors. J Clin Oncol 18:1181–1186
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Kollmannsberger, C. (2015). Platinum-Refractory Testicular Germ Cell Tumors. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_4618-2
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DOI: https://doi.org/10.1007/978-3-642-27841-9_4618-2
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Publisher Name: Springer, Berlin, Heidelberg
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