Definition
Platelet-derived growth factor (PDGF) is a family of growth factors with mitogenic activity for connective tissue cells, such as fibroblasts and smooth muscle cells, as well as for certain other cell types.
Characteristics
PDGF isoforms are disulfide-bonded homodimers of homologous A-, B-, C- and D-polypeptide chains, as well as a heterodimer PDGF-AB. PDGF A- and B-chains are proteolytically processed during secretion from the producer cell, whereas PDGF C- and D-chains are secreted as inactive precursors containing N-terminal CUB domains that need to be cleaved off before these isoforms can bind to receptors. The mature growth factor domain has about 100 amino acid residues with a perfect conservation of 8 cysteine residues. The two subunits in the dimers are arranged antiparallel. In addition to the two interchain disulfide bonds, each subunit contains six additional cysteine residues that are arranged in a characteristic cystine knot structure. The amino acid sequences of...
Keywords
- Vascular Endothelial Cell Growth Factor
- Interstitial Fluid Pressure
- Connective Tissue Cell
- Dermatofibrosarcoma Protuberans
- Autocrine Stimulation
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
Fredriksson L, Li H, Eriksson U (2004) The PDGF family: four gene products form five dimeric isoforms. Cytokine Growth Factor Rev 15:197–204
Heldin C-H, Westermark B (1999) Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 79:1283–1316
Heldin C-H, Östman A, Rönnstrand L (1998) Signal transduction via platelet-derived growth factor receptors. Biochim Biophys Acta 1378:F79–F113
Pietras K, Sjöblom T, Rubin K et al (2003) PDGF receptors as cancer drug targets. Cancer Cell 3:439–443
Rosenkranz S, Kazlauskas A (1999) Evidence for distinct signaling properties and biological responses induced by the PDGF receptor α and β subtypes. Growth Factors 16:201–216
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Heldin, CH. (2015). Platelet-Derived Growth Factor. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_4611-2
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DOI: https://doi.org/10.1007/978-3-642-27841-9_4611-2
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Publisher Name: Springer, Berlin, Heidelberg
Online ISBN: 978-3-642-27841-9
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