Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Plasminogen-Activating System

  • Salvatore Ulisse
  • Enke Baldini
  • Sarah Bocchini
  • Massimino D’Armiento
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4605-2

Definition

The plasminogen-activating system (PAS) consists of two immunologically distinct serine proteases, the urokinase plasminogen activator (uPA) and the tissue-type plasminogen activator (tPA); their specific inhibitors, the plasminogen activator inhibitor 1 (PAI-1) and 2 (PAI-2) and the protease nexin-1 (PN-1), which belong to the serine protease inhibitor superfamily of serpins; and the glycolipid-anchored cell membrane receptor for the uPA. The two plasminogen activators convert, in the extracellular environment, the proenzyme plasminogen into the serine protease plasmin. The latter is involved in fibrin degradation during clot lysis and in a number of physiological and pathological processes requiring basement membrane (BM) and/or extracellular matrix (ECM) remodeling, such as wound healing, mammary gland development and its postlactational involution, tissue regeneration, angiogenesis, tumor progression, and metastasization (Fig. 1). Besides fibrin, in fact, plasmin may...

Keywords

Hepatocyte Growth Factor uPAR Expression Human Epidermoid Carcinoma Cell Line Serine Protease Plasmin Postlactational Involution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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See Also

  1. (2012) Extracellular Matrix. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer, Berlin Heidelberg, p 1362. doi:10.1007/978-3-642-16483-5_2067Google Scholar
  2. (2012) MAPK. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer, Berlin Heidelberg, p 2167. doi:10.1007/978-3-642-16483-5_3532Google Scholar
  3. (2012) P53. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer, Berlin Heidelberg, p 2747. doi:10.1007/978-3-642-16483-5_4331Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Salvatore Ulisse
    • 1
  • Enke Baldini
    • 1
  • Sarah Bocchini
    • 1
  • Massimino D’Armiento
    • 1
  1. 1.Department of Experimental MedicineUniversity of Rome “Sapienza”RomeItaly