“Photochemoprevention” has two very different meanings. The term was first coined in 2001 to describe chemoprevention of skin damage, including skin carcinogenesis (photocarcinogenesis), due to ultraviolet (UV) light (solar ultraviolet light, UV radiation). A second use of the word “photochemoprevention,” as defined in 2003, is to refer to the combination therapy of pulsed dye laser (PDL) to inhibit angiogenesis and chemoprevention to block both proliferation of cancer cells and tumor revascularization (vascular-targeting agents in cancer). The comments below will describe the term “photochemoprevention” as originally used.
Photochemoprevention can refer to the use of any chemopreventive agent, either ingested or topically applied, to block the damaging effects of UV light. UV light, in particular UVB light, is directly responsible for much of the damage leading to skin cancer development, especially basal cell (basal cell carcinoma) and squamous cell...