First, there are at present ten secreted phospholipase A2 enzymes (sPLA2-IB, sPLA2-IIA, sPLA2-IIC, sPLA2-IID, sPLA2-IIE, sPLA2-IIF, sPLA2-III, sPLA2-V, sPLA2-X, and sPLA2-XII), which are of low molecular weight (13–18 kDa) with a catalytic histidine in their active site and a requirement for calcium for enzyme activity.
Second, there are three characterized human cytosolic PLA2 enzymes (cPLA2-α, cPLA2-β, and cPLA2-γ, also known as Group IVA, IVB, and IVC PLA2) that use a catalytic serine in their active site. cPLA2-α and cPLA2-β contain a C2 calcium-binding domain, and enzyme activity is calcium dependent, while cPLA2-γ lacks this domain and is thus a calcium-independent PLA2. Recently, a comprehensive homology search against the murine...
KeywordsArachidonic Acid Arachidonic Acid Release Hydroxyeicosatetraenoic Acid Eicosanoid Synthesis Epoxyeicosatrienoic Acid
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