Pharmacokinetics and Pharmacodynamics in Drug Development
Living reference work entry
To maximize the chance of successful drug development, a comprehensive knowledge of the compound under investigation is required. Assuming the drug target has been correctly selected, drug efficacy requires delivery into the patient such that adequate drug concentration is achieved within the plasma and tumor (measured by PK studies) to effect target modulation (measured by PD studies) resulting in anticancer effect(s). These principles have been incorporated into a pharmacological audit trail consisting of a series of questions that should be addressed during drug design and development. These can be summarized as:
Is the drug target expressed in the tumor of interest?
Are adequate plasma and tumor drug...
KeywordsEpidermal Growth Factor Receptor HSP90 Inhibition Client Protein Target Modulation Human Tumor Xenograft
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