Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Peroxisome Proliferator-Activated Receptor

  • Thomas Barz
  • Dietmar Spengler
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4473-2



Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors originally identified as molecular targets of synthetic compounds inducing peroxisome proliferation. As ligand-dependent transcription factors, PPARs mediate the effects of fatty acids and their derivatives and thereby regulate proliferation, differentiation, and cell survival.


The three peroxisome proliferator-activated receptor isoforms, PPARα, PPARβ/δ, and PPARγ, are encoded by different genes and belong to the largest family of transcription factors, the nuclear hormone receptors (NHRs). PPARs possess a modular structure composed of a central DNA-binding domain (DBD) with two zinc fingers and a ligand-binding domain (LBD), including the ligand-binding pocket and the ligand-dependent activation domain AF-2 in its C terminus (Fig. 1). A ligand-independent, poorly characterized transactivation function at the N terminus is known as AF-1. PPARs control gene...


Adenomatous Polyposis Coli Follicular Thyroid Carcinoma Aberrant Crypt Focus Mutant Adenomatous Polyposis Coli Retinoid Acid Receptor 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Max-Panck-Institut für PsychiatrieMünchenGermany