Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Peroxisome Proliferator-Activated Receptor

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4473-2

Synonyms

Definition

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors originally identified as molecular targets of synthetic compounds inducing peroxisome proliferation. As ligand-dependent transcription factors, PPARs mediate the effects of fatty acids and their derivatives and thereby regulate proliferation, differentiation, and cell survival.

Characteristics

The three peroxisome proliferator-activated receptor isoforms, PPARα, PPARβ/δ, and PPARγ, are encoded by different genes and belong to the largest family of transcription factors, the nuclear hormone receptors (NHRs). PPARs possess a modular structure composed of a central DNA-binding domain (DBD) with two zinc fingers and a ligand-binding domain (LBD), including the ligand-binding pocket and the ligand-dependent activation domain AF-2 in its C terminus (Fig. 1). A ligand-independent, poorly characterized transactivation function at the N terminus is known as AF-1. PPARs control gene...

Keywords

Adenomatous Polyposis Coli Follicular Thyroid Carcinoma Aberrant Crypt Focus Mutant Adenomatous Polyposis Coli Retinoid Acid Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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  5. Mulholland DJ, Dedhar S, Coetzee GA et al (2005) Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know? Endocr Rev 26:898–915CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Max-Panck-Institut für PsychiatrieMünchenGermany