Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Peripheral Neuropathy

  • Stephan Mielke
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4456-2

Synonyms

Definition

Peripheral neuropathy is a general term indicating the malfunction of peripheral nerves due to various causes. Peripheral neuropathies can be categorized by location (distal, proximal), distribution pattern (unilateral, bilateral, symmetrical), underlying cause (toxic, metabolic, vascular, autoimmune, paraneoplastic), impaired neuronal quality (motor, sensory, autonomic), dynamics of manifestation (acute, subacute, chronic), and underlying histopathology (axono-, myelino-, and ganglionopathies).

Characteristics

Depending on the type of peripheral neuropathy and the impaired neuronal qualities, sensory, motor, and autonomic symptoms may appear. Sensory symptoms may include paresthesia, numbness, tingling, burning, and pain, while motor symptoms may range from mild muscular weakness to paralysis. Appearance of orthostatic hypotension, cardiac arrhythmia, and paralytic ileus may reflect autonomic involvement....

Keywords

Peripheral Neuropathy Tuning Fork Paralytic Ileus Sensory Symptom Spinal Cord Dorsal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Antoine JC, Mosnier JF, Absi L et al (1999) Carcinoma associated paraneoplastic peripheral neuropathies in patients with and without anti-onconeural antibodies. J Neurol Neurosurg Psychiatry 67:7–14CrossRefPubMedPubMedCentralGoogle Scholar
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  4. Mielke S, Sparreboom A, Mross K (2006) Peripheral neuropathy: a persisting challenge in paclitaxel-based regimes. Eur J Cancer 42:24–30CrossRefPubMedGoogle Scholar
  5. Roelofs RI, Hrushesky W, Rogin J et al (1984) Peripheral sensory neuropathy and cisplatin chemotherapy. Neurology 34:934–938CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Abteilung Hämatologie und Onkologie, Medizinische Klinik und Poliklinik II, Zentrum Innere Medizin (ZIM)Universitätsklinikum WürzburgWürzburgGermany