Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Peripheral Neuropathy

  • Stephan Mielke
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4456-2



Peripheral neuropathy is a general term indicating the malfunction of peripheral nerves due to various causes. Peripheral neuropathies can be categorized by location (distal, proximal), distribution pattern (unilateral, bilateral, symmetrical), underlying cause (toxic, metabolic, vascular, autoimmune, paraneoplastic), impaired neuronal quality (motor, sensory, autonomic), dynamics of manifestation (acute, subacute, chronic), and underlying histopathology (axono-, myelino-, and ganglionopathies).


Depending on the type of peripheral neuropathy and the impaired neuronal qualities, sensory, motor, and autonomic symptoms may appear. Sensory symptoms may include paresthesia, numbness, tingling, burning, and pain, while motor symptoms may range from mild muscular weakness to paralysis. Appearance of orthostatic hypotension, cardiac arrhythmia, and paralytic ileus may reflect autonomic involvement....


Peripheral Neuropathy Tuning Fork Paralytic Ileus Sensory Symptom Spinal Cord Dorsal 
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© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Abteilung Hämatologie und Onkologie, Medizinische Klinik und Poliklinik II, Zentrum Innere Medizin (ZIM)Universitätsklinikum WürzburgWürzburgGermany