Peptide Vaccines for Cancer
An immunogen composed of synthetic peptides (small protein sequences) administered with the intent of eliciting antitumor immune responses for treating cancer.
Principles of Antitumor Immunity
The immune system has the capacity to recognize tumor cells, and in many instances, this recognition results in antitumor effects such as slowing the tumor growth or tumor eradication. In view of this, many approaches have been made to develop cancer vaccines and other modes of immunotherapy. Cytotoxic T lymphocytes (CTLs) are considered the most effective elements of the immune system that can kill tumor cells. CTLs recognize small fragments (peptides of 8–10 residues) derived from the proteolytic processing of a tumor antigen. These peptides are presented to the CTL antigen receptor in the context of products of the class I major histocompatibility gene complex (MHC) known as HLA class Iin humans. Recognition of peptide/MHC class I complexes that are expressed on...